Therapeutic immunization with an inactivated HIV-1 Immunogen plus antiretrovirals versus antiretroviral therapy alone in asymptomatic HIV-infected subjects

Autor:	Rafael M. Rubio, Marlon Díaz, J Pérez Molina, Carmen Quereda, Juan González-Lahoz, B Clotet, Javier Carbone, Antoni Jou, J A Maradona, R. Blázquez, Elena Ferrer, Stir Team, Eduardo Fernández-Cruz, Inma Ocaña, José Peña, Gatell Jm, M A Muñoz, Jorge A. R. Navarro, Fernando López, Federico Pulido, Santiago Moreno, Juana Gil, Carlos Barros, Luis A. Diaz, M L Abad, Pompeyo Viciana, G Sirera, Emilio Bouza, Daniel Podzamczer, C Cantó, Carmen Rodríguez-Sainz
Rok vydání:	2003
Předmět:	Adult Male Immunogen Anti-HIV Agents Endpoint Determination HIV Infections HIV Envelope Protein gp120 Placebo Asymptomatic Interferon-gamma Pharmacotherapy medicine Humans Sida AIDS Vaccines Immunity Cellular General Veterinary General Immunology and Microbiology biology business.industry Public Health Environmental and Occupational Health virus diseases T-Lymphocytes Helper-Inducer Th1 Cells biology.organism_classification Combined Modality Therapy Lymphoproliferative Disorders Vaccination Infectious Diseases Vaccines Inactivated Lentivirus Immunology HIV-1 Molecular Medicine Female medicine.symptom Chemokines business Viral load
Zdroj:	Vaccine. 22(23-24)
ISSN:	0264-410X
Popis:	To determine whether the addition of an inactivated-gp120-depleted HIV-1 Immunogen to antiretrovirals (ARTs) conferred a beneficial effect on delaying time to virologic failure relative to that obtained by ARTs alone, a phase II clinical trial was performed in 243 asymptomatic, ART naive, HIV-1 seropositive adults. The Cox model showed that HIV-1 Immunogen treatment was associated with a 34% decrease in the risk of virologic failure (P = 0.056). When the analysis incorporated baseline HIV-RNA stratification the risk of virologic failure in the HIV-1 Immunogen Arm was significantly reduced a 37% compared to the IFA placebo Arm (P = 0.034). The data suggest that therapeutic immunization plus ARTs could influence virologic control.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c19e8b5ed3c4be396fa47fdb64da8e https://pubmed.ncbi.nlm.nih.gov/15297045 Zobrazit plný text záznamu Full Text from ScienceDirect