Sparfloxacin, ethambutol, and cortisol receptor inhibitor RU-40 555 treatment for disseminated Mycobacterium avium complex infection of normal C57BL/6 mice
| Autor: | C Truffot-Pernot, Y Cohen, J Grosset, Jean-Jacques Pocidalo, Jean-Louis Vildé, C Perronne |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
C57BL/6
Time Factors medicine.drug_class medicine.medical_treatment Antibiotics Microbial Sensitivity Tests Quinolones Pharmacology Mice Receptors Glucocorticoid medicine Animals Tuberculosis Pharmacology (medical) Glucocorticoids Ethambutol Antibacterial agent Chemotherapy biology business.industry Mifepristone bacterial infections and mycoses Antimicrobial biology.organism_classification Anti-Bacterial Agents Mice Inbred C57BL Disease Models Animal Infectious Diseases Sparfloxacin Feasibility Studies Drug Therapy Combination Female business Spleen Fluoroquinolones Mycobacterium avium Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 36:2408-2412 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Sparfloxacin (50 mg/kg of body weight given subcutaneously each day), alone or in combination with ethambutol (50 mg/kg given subcutaneously each day), was examined for its therapeutic efficacy against experimental infection induced with the Mycobacterium avium complex in normal C57BL/6 mice. In addition, the potential anti-infective role of RU-40 555 (100 mg/kg given intraperitoneally each day), a drug that inhibits the cortisol receptors, was examined in the same model. Treatments were started 24 h after intravenous bacterial challenge and were continued for 21 days. Compared with controls, sparfloxacin or ethambutol decreased the CFU counts in spleens and lungs (P < 0.001). The sparfloxacin plus ethambutol combination was more effective than sparfloxacin alone in spleens (P < 0.001) but not in lungs. The sparfloxacin plus ethambutol plus RU-40 555 combination was more effective than the sparfloxacin plus ethambutol combination in spleens and lungs (P < 0.001). Thus, in this model, RU-40 555 enhanced the antibacterial activities of the antibiotics tested. Results of the study showed that normal C57BL/6 mice infected with the M. avium complex can be used for the evaluation of antimicrobial agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|