Association between interleukin-6 gene promoter −572C/G polymorphism and the risk of sporadic Alzheimer’s disease
| Autor: | Wan-li Yang, Jin-sheng Zeng, Ming-ming Zhang, Lirong Zhang, Yajun Lian, Mei-xia He, Hai-ying Hua |
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| Rok vydání: | 2009 |
| Předmět: |
Male
China medicine.medical_specialty Genotype medicine.medical_treatment Dermatology Asian People Gene Frequency Alzheimer Disease Polymorphism (computer science) Internal medicine Odds Ratio medicine Humans Genetic Predisposition to Disease Allele Promoter Regions Genetic Interleukin 6 Allele frequency Gene Aged 80 and over Polymorphism Genetic biology Interleukin-6 Promoter Sequence Analysis DNA General Medicine Molecular biology Psychiatry and Mental health Logistic Models Cytokine Endocrinology biology.protein Female Neurology (clinical) |
| Zdroj: | Neurological Sciences. 31:165-168 |
| ISSN: | 1590-3478 1590-1874 |
| DOI: | 10.1007/s10072-009-0199-3 |
| Popis: | Inflammation is a key component of Alzheimer's disease (AD), and we have examined the effect of two polymorphisms (-174G/C and -572C/G) in the promoter of the inflammatory cytokine interleukin-6 (IL-6) gene on risk of AD in 318 AD patients. Significant differences in genotype and allele frequencies of -572C/G IL-6 promoter polymorphism were observed between AD patients and controls. The GG genotype was associated with a decreased risk of developing AD (OR 0.423, 95% CI 0.200-0.894). Similarly, logistic regression analysis revealed that G allele was a protective factor for AD (OR 0.732, 95% CI 0.567-0.945). For -174G/C variability, no C variability was found in all the subjects. The frequency of the IL-6 -174G/C promoter polymorphism is very low or no variability in Henan Han population. The -572C/G polymorphism of IL-6 gene promoter region is associated with AD, and G allele is an independent protective factor for AD. |
| Databáze: | OpenAIRE |
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