Association between erythrocyte mean corpuscular volume and peripheral arterial disease in male subjects: a case control study
| Autor: | Meinhard Haltmayer, Thomas Mueller, Dieter Haidinger, Christian Luft, Werner Horvath, Werner Poelz |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Erythrocyte Indices Male medicine.medical_specialty Population Arterial Occlusive Diseases 030204 cardiovascular system & hematology Gastroenterology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Medicine Humans 030212 general & internal medicine Erythrocyte Mean Corpuscular Volume Risk factor education Mean corpuscular volume Homocysteine Aged Aged 80 and over education.field_of_study medicine.diagnostic_test business.industry Vascular disease Smoking gamma-Glutamyltransferase Middle Aged medicine.disease Surgery Vitamin B 12 Regression Analysis Cardiology and Cardiovascular Medicine business Increased mean corpuscular volume |
| Zdroj: | Angiology. 52(9) |
| ISSN: | 0003-3197 |
| Popis: | Elevated serum total homocysteine, an established risk factor for peripheral arterial disease, is influenced by the vitamin B12 and folate status. Since these vitamins are inversely correlated with erythrocyte mean corpuscular volume, an investigation of whether mean corpuscular volume is higher in patients with symptomatic peripheral arterial disease than in healthy subjects was performed. Furthermore, a determination of predictors of increased mean corpus cular volume levels in this population free of symptomatic coronary artery disease, cere brovascular disease, and diabetes mellitus was carried out. From 469 consecutive patients with symptomatic peripheral arterial disease, 100 fulfilled study inclusion criteria. Peripheral arterial disease was confirmed by angiography. One hundred age-matched subjects without peripheral arterial disease as verified by ankle-brachial index measurements > 0.9 served as control subjects. Patients with PAD displayed a significantly higher mean corpuscular volume level (94.5 fl) than control subjects (90.9 fl, p< 0.001). Logistic regression analysis showed that current smoking status (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|