Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells
| Autor: | Sung-Hoon Kim, Eun-Ok Lee, Hyo-Jeong Lee, Seon-Ok Lee, Myoung-Sun Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
LNCaP lambertianic acid androgen receptor anticancer Carboxylic Acids Apoptosis Cell Cycle Proteins lcsh:Chemistry 0302 clinical medicine Nandrolone Cyclin D1 RNA Small Interfering lcsh:QH301-705.5 Spectroscopy bcl-2-Associated X Protein biology Caspase 3 Chemistry General Medicine Caspase 9 Computer Science Applications Proto-Oncogene Proteins c-bcl-2 Biochemistry Receptors Androgen 030220 oncology & carcinogenesis RNA Interference medicine.symptom Down-Regulation Antineoplastic Agents Naphthalenes Article Catalysis Inorganic Chemistry 03 medical and health sciences Bcl-2-associated X protein Cell Line Tumor medicine Humans Physical and Theoretical Chemistry Molecular Biology Cell Proliferation Cell growth Organic Chemistry Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Prostate-Specific Antigen G1 Phase Cell Cycle Checkpoints 030104 developmental biology Mechanism of action lcsh:Biology (General) lcsh:QD1-999 biology.protein Cancer research Cyclin-dependent kinase 6 Tumor Suppressor Protein p53 |
| Zdroj: | International Journal of Molecular Sciences, Vol 17, Iss 7, p 1066 (2016) International Journal of Molecular Sciences; Volume 17; Issue 7; Pages: 1066 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(17): 7 International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Lambertianic acid (LA) is known to have anti-allergic and antibacterial effects. However, the anticancer activities and mechanism of action of LA have not been investigated. Therefore, the anticancer effects and mechanism of LA are investigated in this study. LA decreased not only AR protein levels, but also cellular and secretory levels of PSA. Furthermore, LA inhibited nuclear translocation of the AR induced by mibolerone. LA suppressed cell proliferation by inducing G(1) arrest, downregulating CDK4/6 and cyclin D1 and activating p53 and its downstream molecules, p21 and p27. LA induced apoptosis and the expression of related proteins, including cleaved caspase-9 and -3, c-PARP and BAX, and inhibited BCl-2. The role of AR in LA-induced apoptosis was assessed by using siRNA. Collectively, these findings suggest that LA exerts the anticancer effect by inhibiting AR and is a valuable therapeutic agent in prostate cancer treatment. |
| Databáze: | OpenAIRE |
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