Unexpected Copper-Catalyzed Cascade Synthesis of Quinazoline Derivatives

Autor:	Miaochang Liu, Wenxia Gao, Xiaobo Huang, Jiuxi Chen, Huayue Wu, Zhongyan Chen, Jinchang Ding
Rok vydání:	2013
Předmět:	Quinazoline derivatives Cerium nitrate hexahydrate Molecular Structure Organic Chemistry Catalysis chemistry.chemical_compound Cascade reaction chemistry Cascade Quinazolines Copper catalyzed Organic chemistry Ammonium chloride Copper
Zdroj:	The Journal of Organic Chemistry. 78:11342-11348
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo401908g
Popis:	The first example of a copper-catalyzed cascade reaction of (2-aminophenyl)methanols with aldehydes using the combination of cerium nitrate hexahydrate and ammonium chloride has been developed, leading to a wide range of 2-substituted quinazolines in moderate to excellent yields. The efficiency of this transformation was demonstrated by compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of 2-substituted quinazoline derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bd2214bd2624e92814cc0628a07437 https://doi.org/10.1021/jo401908g Zobrazit plný text záznamu