Multidisciplinary Management of Locally Advanced and Metastatic Cutaneous Squamous Cell Carcinoma
| Autor: | J Archambault, Joël Claveau, Carman A. Giacomantonio, F Parent, Christian Murray, David Zloty, J J Limacher, D S Ernst |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Skin Neoplasms Cutaneous squamous cell carcinoma medicine.medical_treatment Locally advanced Systemic therapy 03 medical and health sciences stratification 0302 clinical medicine Multidisciplinary approach Internal medicine multidisciplinary management medicine Humans 030212 general & internal medicine Neoplasm Metastasis locally advanced disease Cetuximab business.industry staging Radiation therapy Patient classification 030220 oncology & carcinogenesis Carcinoma Squamous Cell Curative surgery business metastatic disease medicine.drug |
| Zdroj: | Current Oncology Volume 27 Issue 4 Pages 6015-407 |
| ISSN: | 1718-7729 |
| DOI: | 10.3747/co.27.6015 |
| Popis: | Non-melanoma skin cancers are the most prevalent form of cancer, with cutaneous squamous cell carcinoma (cSCC) being the 2nd most common type. Patients presenting with high-risk lesions associated with locally advanced or metastatic cSCC face high rates of recurrence and mortality. Accurate staging and risk stratification for patients can be challenging because no system is universally accepted, and no Canadian guidelines currently exist. Patients with advanced cSCC are often deemed ineligible for either or both of curative surgery and radiation therapy (RT) and, until recently, were limited to off-label systemic cisplatin–fluorouracil or cetuximab therapy, which offers modest clinical benefits and potentially severe toxicity. A new systemic therapy, cemiplimab, has been approved for the treatment of locally advanced and metastatic cSCC. In the present review, we provide recommendations for patient classification and staging based on current guidelines, direction for determining patient eligibility for surgery and RT, and an overview of the available systemic treatment options for advanced cSCC and of the benefits of a multidisciplinary approach to patient management. |
| Databáze: | OpenAIRE |
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