High-Density Lipoprotein Carries Markers That Track With Recovery From Stroke
| Autor: | Wayne M. Clark, Paige Bergstrom, Phillip A. Wilmarth, Deanna L. Plubell, Sergio Fazio, Sara Rosario, Neil A. Zakai, Nathalie Pamir, Alex M. Fenton, Nabil J. Alkayed, Jessica Minnier, Joseph F. Quinn |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Proteome Receptors Peptide Physiology Proteinase Inhibitory Proteins Secretory Glycosylphosphatidylinositol Diacylglycerol-Lyase Article Cell Line Stroke risk Mice chemistry.chemical_compound High-density lipoprotein Internal medicine medicine Animals Humans Hedgehog Proteins Prospective cohort study Stroke Aged Lipoprotein cholesterol Membrane Glycoproteins Aryldialkylphosphatase business.industry Cholesterol Recovery of Function Middle Aged medicine.disease Apolipoproteins chemistry Cardiology Female Lipoproteins HDL Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Circ Res |
| ISSN: | 1524-4571 0009-7330 |
| Popis: | Rationale: Prospective cohort studies question the value of HDL-C (high-density lipoprotein cholesterol) for stroke risk prediction. Objective: Investigate the relationship between long-term functional recovery and HDL proteome and function. Methods and Results: Changes in HDL protein composition and function (cholesterol efflux capacity) in patients after acute ischemic stroke at 2 time points (24 hours, 35 patients; 96 hours, 20 patients) and in 35 control subjects were measured. The recovery from stroke was assessed by 3 months, the National Institutes of Health Stroke Scale and modified Rankin scale scores. When compared with control subject after adjustments for sex and HDL-C levels, 12 proteins some of which participate in acute phase response and platelet activation (APMAP [adipocyte plasma membrane-associated protein], GPLD1 [phosphate inositol-glycan specific phospholipase D], APOE [apolipoprotein E], IHH [Indian hedgehog protein], ITIH4 [inter-alpha-trypsin inhibitor chain H4], SAA2 [serum amyloid A2], APOA4 [apolipoprotein A-IV], CLU [clusterin], ANTRX2 [anthrax toxin receptor 2], PON1 [serum paraoxonase/arylesterase], SERPINA1 [alpha-1-antitrypsin], and APOF [apolipoprotein F]) were significantly (adjusted P P R 2 =0.38–0.73, adjusted P R 2 =0.73) and APOL1 ( R 2 =0.60) continued to significantly correlate with recovery scores after accounting for tPA (tissue-type plasminogen activator) treatment. Conclusions: Changes in HDL proteins during early acute phase of stroke associate with recovery. Monitoring HDL proteins may provide clinical biomarkers that inform on stroke recuperation. |
| Databáze: | OpenAIRE |
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