Inhibition of Curcumin on ZAKα Activity Resultant in Apoptosis and Anchorage- Independent Growth in Cancer Cells
Autor: | Jin-Sun Lee, Tsu-Shing Wang, Ming Cheng Lin, Jaw-Ji Yang, Wei-Wen Lin |
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Rok vydání: | 2017 |
Předmět: |
Cyclin-Dependent Kinase Inhibitor p21
MAPK/ERK pathway Curcumin Physiology Antineoplastic Agents Apoptosis 030209 endocrinology & metabolism 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Line Tumor Physiology (medical) Humans Protein kinase A Protein Kinase Inhibitors Cell Proliferation MAP kinase kinase kinase Chemistry Kinase Cell growth Cell Cycle Cell cycle MAP Kinase Kinase Kinases Cancer cell Cancer research Protein Kinases Cyclin-Dependent Kinase Inhibitor p27 |
Zdroj: | The Chinese Journal of Physiology. 60:267-274 |
ISSN: | 0304-4920 |
Popis: | Curcumin, a popular yellow pigment of the dietary spice turmeric, has been reported to inhibit cell growth and to induce apoptosis in a wide variety of cancer cells. Although numerous studies have investigated anticancer effects of curcumin, the precise molecular mechanism of action remains unidentified. Whereas curcumin mediates cell survival and apoptosis through mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling cascades, its impact on the upstream regulation of MAPK is unclear. The leucine-zipper and sterile-α motif kinase alpha (ZAKα), a mitogen-activated protein kinase kinase kinase (MAP3K), activates the c-Jun N-terminal kinase (JNK) and NF-κB pathway. This paper investigated the prospective involvement of ZAKα in curcumin-induced effects on cancer cells. Our results suggest that the antitumor activity of curcumin is mediated via a mechanism involving inhibition of ZAKα activity. |
Databáze: | OpenAIRE |
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