Prevalence and Characteristics of Hepatitis Delta Virus Infection in a Tertiary Hospital Setting in Cameroon
| Autor: | Olivier Donfack-Sontsa, Dominique Noah Noah, Servais Albert Fiacre Bagnaka Eloumou, Georges B. Nko’Ayissi, Cecile Okalla, Agnes Malongue, Henry Namme Luma, Ruth Koumitana |
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| Rok vydání: | 2017 |
| Předmět: |
Hepatitis B virus
HBsAg medicine.medical_specialty Hepatology business.industry viruses virus diseases biochemical phenomena metabolism and nutrition medicine.disease_cause medicine.disease 03 medical and health sciences Liver disease 0302 clinical medicine HBeAg 030220 oncology & carcinogenesis Internal medicine Hepatocellular carcinoma Epidemiology Immunology medicine Coinfection 030211 gastroenterology & hepatology Original Article Hepatitis D virus business |
| Zdroj: | Journal of clinical and experimental hepatology. 7(4) |
| ISSN: | 0973-6883 |
| Popis: | Background/Aims Hepatitis B virus (HBV) and hepatitis D virus (HDV) coinfection is associated with more severe liver disease than HBV alone. More knowledge on the epidemiology and clinical impact of HDV-infected individuals is needed in Cameroon. We aimed at determining the frequency of anti-HDV antibody testing in hepatitis B surface antigen (HBsAg) positive patients, the proportion of anti-HDV positivity, and the characteristics of anti-HDV positive compared to anti-HDV negative patients in a tertiary hospital setting in Cameroon. Methods A cross-sectional study was conducted. Clinical records of chronic HBV-infected patients attending the gastroenterology unit at the Douala General Hospital from 2010 to 2014 were reviewed. Results Of 365 files of HBsAg-positive patients defined as chronic HBV infection, 80.5% (294) were tested for anti-HDV antibodies, among whom 10.5% (31/294) were positive. Median aspartate aminotransferase ( P P P P P P P P Conclusion The proportion of anti-HDV antibody positivity remains high in this setting and was significantly associated with more severe liver disease compared to those who were anti-HDV negative. More studies are needed to evaluate rates of HDV testing in other centers in Cameroon and the subregion. Preventive strategies for HBV prevention, which also apply to HDV, must still be reinforced by healthcare providers and policy makers. |
| Databáze: | OpenAIRE |
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