Altered Expression of Proteins of Metabolic Regulation during Remodeling of the Left Ventricle after Myocardial Infarction

Autor: Christophe Albert Montessuit, Isabelle Tardy, Irène Papageorgiou, Nathalie Rosenblatt-Velin, René Lerch, Andrea Remondino, Manuel Jorge-Costa, Pierre-André Dorsaz
Rok vydání: 2000
Předmět:
Male
medicine.medical_specialty
Monosaccharide Transport Proteins
Myocardial Infarction
Palmitates
Muscle Proteins
Infarction
Nerve Tissue Proteins
Biology
Fatty Acid-Binding Proteins
Acyl-CoA Dehydrogenase
chemistry.chemical_compound
Left coronary artery
Acyl-CoA Dehydrogenases
medicine.artery
Internal medicine
medicine
Animals
RNA
Messenger
Myocardial infarction
Rats
Wistar
Molecular Biology
Glucose Transporter Type 1
Glucose Transporter Type 4
Ventricular Remodeling
Fatty acid metabolism
Glucose transporter
Metabolism
medicine.disease
Neoplasm Proteins
Rats
Glucose
Endocrinology
Gene Expression Regulation
chemistry
Coronary occlusion
Heart-type fatty acid binding protein
Hypertrophy
Left Ventricular
Carrier Proteins
Energy Metabolism
Fatty Acid-Binding Protein 7
Cardiology and Cardiovascular Medicine
Zdroj: Journal of Molecular and Cellular Cardiology. 32:2025-2034
ISSN: 0022-2828
DOI: 10.1006/jmcc.2000.1234
Popis: Non-infarcted myocardium after coronary occlusion undergoes progressive morphological and functional changes. The purpose of this study was to determine whether non-infarcted myocardium exhibits (1) alteration of the substrate pattern of myocardial metabolism and (2) concomitant changes in the expression of regulatory proteins of glucose and fatty acid metabolism. Myocardial infarction was induced in rats by ligation of the left coronary artery. One day and eight weeks after coronary occlusion, glucose and palmitate oxidation were measured. Expression of selected proteins of metabolism were determined one day to 12 weeks after infarction. One day after coronary occlusion no difference of glucose and palmitate oxidation was detectable, whereas after eight weeks, glucose oxidation was increased (+84%, P
Databáze: OpenAIRE
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