Assessment of the effect of gasoline fume on stress hormones, antioxidant status and lipid peroxidation in albino rat
| Autor: | Wasiu Eniola Olooto, A. A. Aladesida, G. A. Dedeke, Folarin O. Owagboriaye, J. A. Bamidele |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Environmental pollution Adrenocorticotropic hormone 010501 environmental sciences medicine.disease_cause 01 natural sciences Toxicology Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Corticosterone Internal medicine medicine otorhinolaryngologic diseases General lcsh:Science (General) 0105 earth and related environmental sciences Inhalation exposure Multidisciplinary Aldosterone Inhalation respiratory tract diseases 030104 developmental biology Endocrinology chemistry Oxidative stress lcsh:Q1-390 |
| Zdroj: | Journal of King Saud University: Science, Vol 30, Iss 3, Pp 393-399 (2018) |
| ISSN: | 1018-3647 |
| Popis: | Gasoline fume has been considered a major air pollutant affecting the heart, lungs, brain, liver and kidneys. Therefore, this study aims at investigating the effect of inhalation exposure to gasoline fume on some endogenic stress hormones and oxidative enzymes of albino rats. Forty adult male albino rats were randomly assigned to five experimental treatments (T) with eight rats per treatment (T1, T2, T3, T4 and T5). The control treatment, T1 was housed in a section of experimental animal house free from gasoline fumes while T2, T3, T4 and T5 were exposed to gasoline fumes in exposure chambers for one, three, five and nine hours daily respectively for twelve weeks. The levels of adrenocorticotropic hormone (ACTH), aldosterone and corticosterone were determined using enzyme-linked immunosorbent assay (ELISA) kits. Concentrations of oxidative stress marker (GSH, CAT, MDA and BuChE) were assayed using standard method. Levels of ACTH were recorded to significantly reduce in the gasoline fume exposed rats when compared to control. Aldosterone and corticosterone significantly increase with increase in the daily period of gasoline fume exposure relative to the control. Values of ACTH negatively correlate with those of corticosterone and aldosterone in the exposed rats. The values of GSH, CAT and BuChE were significantly higher in the control rats and significantly reduce with increasing daily exposure time to gasoline fume. MDA concentration was lower in control rats but significantly increased with increasing daily exposure time to gasoline fume. Inhalation exposure to gasoline fume was observed to induce stress in the exposed animals. Keywords: Oxidative stress, Gasoline fume, Environmental pollution, Adrenal hormones, Inhalation |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|