Expression of microRNA-218 and its clinicopathological and prognostic significance in human glioma cases
| Autor: | Gu-Yu Hu, Mao-Wei Cheng, Ling-Ling Wang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Male Cancer Research Pathology medicine.medical_specialty Multivariate analysis Epidemiology Down-Regulation Kaplan-Meier Estimate Biology Disease-Free Survival Downregulation and upregulation Glioma Internal medicine microRNA medicine Biomarkers Tumor Tumor Cells Cultured Humans Survival analysis Regulation of gene expression Proportional hazards model Public Health Environmental and Occupational Health Brain Middle Aged medicine.disease Survival Analysis Gene Expression Regulation Neoplastic MicroRNAs Astrocytes Biomarker (medicine) Female |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 16(5) |
| ISSN: | 2476-762X |
| Popis: | Background: MicroRNAs are a class of noncoding RNAs which regulate multiple cellular processes during tumor development. The purpose of this report is to investigate the clinicopathological and prognostic significance of miR-218 in human gliomas. Materials and Methods: Quantitative RT-PCR (qRT-PCR) was conducted to detect the expression of miR-218 in primary normal human astrocytes, three glioma cell lines and 98 paired glioma and adjacent normal brain tissues.Associations of miR-218 with clinicopathological variables of glioma patients were statistically analyzed. Finally, a survival analysis was performed using the Kaplan-Meier method and Cox's proportional hazards model. Results: The expression level of miR-218 in primary normal human astrocytes was significantly higher than that in glioma cell lines ( p |
| Databáze: | OpenAIRE |
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