Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives

Autor: Roberta Jeane Bezerra Jorge, Francisco Assis Nogueira Júnior, Cayo Almeida, Joeliton dos Santos Cavalcante
Přispěvatelé: Universidade Estadual Paulista (UNESP), Federal University of ABC
Rok vydání: 2021
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 0041-0101
DOI: 10.1016/j.toxicon.2021.08.016
Popis: Made available in DSpace on 2022-04-29T08:32:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-15 Snake venoms are substances mostly composed by proteins and peptides with high biological activity. Local and systemic effects culminate in clinical manifestations induced by these substances. Pain is the most uncomfortable condition, but it has not been well investigated. This review discusses Bothrops snakebite-induced nociception, highlighting molecules involved in the mediation of this process and perspectives in treatment of pain induced by Bothrops snake venoms (B. alternatus, B. asper, B. atrox, B. insularis, B. jararaca, B. pirajai, B. jararacussu, B. lanceolatus, B. leucurus, B. mattogrossensis, B. moojeni). We highlight, the understanding of the nociceptive signaling, especially in snakebite, enables more efficient treatment approaches. Finally, future perspectives for pain treatment concerning snakebite patients are discussed. Graduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University Department of Physiology and Pharmacology and Drug Research and Development Center Federal University of Ceará Center of Mathematics Computing Sciences and Cognition Federal University of ABC Graduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University
Databáze: OpenAIRE
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