Flow cytometric DNA ploidy and recurrence development in squamous cell carcinoma of the oral cavity

Autor:	E Raubenheimer, W VanHeerden, E Schon, J Kreidler, J Hemmer
Rok vydání:	1996
Předmět:	Cancer Research Pathology medicine.medical_specialty Cell Cancer Aneuploidy Biology Cell cycle medicine.disease Primary tumor medicine.anatomical_structure Oncology medicine Progenitor cell Ploidy Radical surgery
Zdroj:	International Journal of Oncology. 8:113-116
ISSN:	1791-2423 1019-6439
DOI:	10.3892/ijo.8.1.113
Popis:	This prospective study on 348 patients with oral squamous cell carcinoma who underwent radical surgery established a close association between the DNA ploidy status of the primary tumor and the risk of local recurrence development. Nine percent of patients with flow cytometrically diploid tumors developed a recurrence compared to 46% of those with aneuploid tumors. This correlation held true even if evaluated with respect to tumor stage or histological grade. Thirteen percent of the diploid and 59% of the aneuploid group showed lymph node metastasis. These results provide substantial evidence that cytogenetic events that underlie aneuploidy formation from initially diploid progenitor cells are functionally linked to the development of tumor cell populations that have the capability to establish independently growing colonies in foreign tissues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b1de3575802a4c7389435f671984d9 https://doi.org/10.3892/ijo.8.1.113 Zobrazit plný text záznamu