EORTC QLU-C10D value sets for Austria, Italy, and Poland

Autor: Francesco Cottone, Georg Kemmler, Richard Norman, Bernhard Holzner, Madeleine King, F. Efficace, Eva Gamper
Rok vydání: 2020
Předmět:
Zdroj: Quality of Life Research
ISSN: 1573-2649
0962-9343
DOI: 10.1007/s11136-020-02536-z
Popis: Objective To develop Austrian, Italian, and Polish general population value sets for the EORTC QLU-C10D, a cancer-specific utility instrument based on the EORTC QLQ-C30, and to descriptively compare their index scores for distinct health states. Methods The QLU-C10D descriptive system comprises 10 health attributes and each can take on 4 levels. A standardised and pre-tested methodology has been applied for valuations including a web-based discrete choice experiment (DCE). It was administered in 1000 general population respondents per country recruited via online panels, aiming at representativeness for core socio-demographic variables. Results In all three countries, the attributes with the largest impact on utility were physical functioning, pain, and role functioning. Cancer-specific dimensions with the largest impact were nausea and fatigue or bowel problems. Utility values of the worst health state (i.e. severe problems on all 10 dimension) were -0.111 (Austria), 0.025 (Italy), and 0.048 (Poland). Country-specific utilities differed for a selection of health states across the continuum. Austrian utilities were systematically lower for moderately and severely impaired health states. Conclusion QLU-C10D cancer-specific utilities can now be calculated in three more countries. Differences between countries indicate that careful consideration is required when using non-country-specific value sets in economic evaluations.
Databáze: OpenAIRE
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