Theranostic Approach for the Protein Corona of Polysaccharide Nanoparticles
| Autor: | Jiri Skladanka, Branislav Ruttkay-Nedecky, René Kizek, Bozena Hosnedlova, Veronika Mlejnková, Sylvie Skalickova, Pavel Horky, Carlos Fernandez |
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| Rok vydání: | 2020 |
| Předmět: |
General Chemical Engineering
Nanoparticle Nanotechnology Protein Corona 010402 general chemistry Polysaccharide 01 natural sciences Biochemistry Theranostic Nanomedicine Chitosan chemistry.chemical_compound Adjuvants Immunologic Polysaccharides Neoplasms Materials Chemistry Humans Disease markers Inorganic particles chemistry.chemical_classification 010405 organic chemistry General Chemistry Atherosclerosis Structural chemistry Immunity Humoral 3. Good health 0104 chemical sciences chemistry Drug delivery Nanoparticles Biomarkers |
| Zdroj: | The Chemical Record. 21:17-28 |
| ISSN: | 1528-0691 1527-8999 |
| Popis: | Polysaccharide nanoparticles are promising materials in the wide range of disciplines such as medicine, nutrition, food production, agriculture, material science and others. They excel not only in their non-toxicity and biodegradability but also in their easy preparation. As well as inorganic particles, a protein corona (PC) around polysaccharide nanoparticles is formed in biofluids. Moreover, it has been considered that the overall response of the organism to nanoparticles presence depends on the PC. This review summarises scientific publications about the structural chemistry of polysaccharide nanoparticles and their impact on theranostic applications. Three strategies of implementation of the PC in theranostics have been discussed: I) Utilisation of the PC in therapy; II) How the composition of the PC is analysed for specific disease markers; III) How the formed PC can interact with the immune system and enhances the immunomodulation or immunoelimination. Thus, the findings from this review can contribute to improve the design of drug delivery systems. However, it is still necessary to elucidate the mechanisms of nano-bio interactions and discover new connections in nanoscale research. |
| Databáze: | OpenAIRE |
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