Sleep and circadian disruption and the gut microbiome-possible links to dysregulated metabolism
| Autor: | Antonio Gonzalez, Samuel J. Bowers, Kenneth P. Wright, Amy C. Reynolds, Dana Withrow, Christopher M. Depner |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Circadian disruption Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Inflammation Metabolism Biology Bioinformatics Sleep in non-human animals Article Gut microbiome body regions Positive energy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine Circadian rhythm medicine.symptom Metabolic health |
| Zdroj: | Curr Opin Endocr Metab Res |
| ISSN: | 2451-9650 |
| Popis: | Insufficient sleep and circadian misalignment are associated with adverse metabolic health outcomes. Alterations in gut microbial diversity occur with insufficient sleep and circadian misalignment, which can lead to modifications in microbial structure and function. Changes in microbially produced and modified metabolites such as short chain fatty acids and secondary bile acids may contribute to chronic inflammation, positive energy balance and endocrine changes, and represent potential mechanisms linking insufficient sleep and circadian misalignment with metabolic dysregulation. Literature primarily from the last two years is reviewed here, examining the impact of sleep and circadian rhythms and their disruption on the gut microbiome in human and non-human models, with an emphasis on the hypothesis that the altered gut microbiome may be one pathway by which insufficient sleep and circadian misalignment dysregulate metabolism. |
| Databáze: | OpenAIRE |
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