Adiponectin levels during low- and high-fat eucaloric diets in lean and obese women
| Autor: | Jeanine Albu, Evan S. Berk, Carol N. Boozer, F. X. Pi-Sunyer, Julia A. Johnson, Albert J. Kovera |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Blood Glucose Leptin medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Medicine (miscellaneous) Calorimetry Fatty Acids Nonesterified Article Endocrinology Insulin resistance Thinness Internal medicine High fat Medicine Humans Insulin Obesity Analysis of Variance Adiponectin business.industry Public Health Environmental and Occupational Health nutritional and metabolic diseases Insulin sensitivity medicine.disease Dietary Fats Magnetic Resonance Imaging Female Analysis of variance Insulin Resistance business hormones hormone substitutes and hormone antagonists Food Science |
| Zdroj: | Obesity research. 13(9) |
| ISSN: | 1071-7323 |
| Popis: | Objective: Adiponectin influences insulin sensitivity (SI) and fat oxidation. Little is known about changes in adiponectin with changes in the fat content of eucaloric diets. We hypothesized that dietary fat content may influence adiponectin according to an individual's SI. Research Methods and Procedures: We measured changes in adiponectin, insulin, glucose, and leptin in response to high-fat (HF) and low-fat (LF) eucaloric diets in lean (n = 10) and obese (n = 11) subjects. Obese subjects were further subdivided in relation to a priori SI. Results: We found significantly higher insulin, glucose, and leptin and lower adiponectin in obese vs. lean subjects during both HF and LF. The mean group values of these measurements, including adiponectin (lean, HF 21.9 ± 9.8; LF, 20.8 ± 6.6; obese, HF 10.0 ± 3.3; LF, 9.5 ± 2.3 ng/mL; mean ± SD), did not significantly change between HF and LF diets. However, within the obese group, the insulin-sensitive subjects had significantly higher adiponectin during HF than did the insulin-resistant subjects. Additionally, the change in adiponectin from LF to HF diet correlated positively with the obese subjects’ baseline SI. Discussion: Although in lean and obese women, group mean values for adiponectin did not change significantly with a change in fat content of a eucaloric diet, a priori measured SI in obese subjects predicted an increase in adiponectin during the HF diet; this may be a mechanism that preserves SI in an already obese group. |
| Databáze: | OpenAIRE |
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