Extension of bladder-based organ regeneration platform for tissue engineering of esophagus
| Autor: | Manuel J. Jayo, Elias A. Rivera, John W. Ludlow, Deepak Jain, Toyin Knight, Timothy A. Bertram, Kelly I. Guthrie, Richard G. Payne, Christopher W. Genheimer, Kim L. Mihalko, Joydeep Basu, Namrata Sangha |
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| Rok vydání: | 2012 |
| Předmět: |
Myocytes
Smooth Muscle Urinary Bladder Population Adipose tissue Matrix (biology) Biology Regenerative Medicine Regenerative medicine Esophagus Tissue engineering Absorbable Implants medicine Animals Regeneration Myocyte education education.field_of_study Tissue Engineering Tissue Scaffolds Regeneration (biology) General Medicine Anatomy Rats Cell biology medicine.anatomical_structure Rats Inbred Lew Female |
| Zdroj: | Medical Hypotheses. 78:231-234 |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2011.10.032 |
| Popis: | Recent successes in regenerative medicine and tissue engineering of bladder and bladder-like neo-organs have leveraged regenerative constructs composed of a biodegradable scaffold seeded with a population of smooth muscle cells. We have shown that such smooth muscle cells are isolatable from adipose and other sources alternate to the primary organ. We hypothesize that this regenerative platform is not limited to regeneration of bladder and bladder-like neo-organs, but rather represents a foundational technology platform broadly applicable for regeneration of laminarly organized hollow organs. Using esophagus as an illustrative example in support of this hypothesis, we demonstrate that patch constructs composed of adipose-derived smooth muscle cells seeded on a biodegradable matrix catalyze complete regeneration of the esophageal wall in a rodent model of esophageal injury. By implication, such regenerative constructs may potentially be used to mediate the regeneration of any laminarly organized tubular organ. |
| Databáze: | OpenAIRE |
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