Factors predicting publication of spinal cord injury trials registered on www.ClinicalTrials. gov

Autor:	Alan H. Daniels, J. Mason DePasse, Sara Park, Adam E.M. Eltorai
Rok vydání:	2018
Předmět:	medicine.medical_specialty Alternative medicine Psychological intervention Physical Therapy Sports Therapy and Rehabilitation 03 medical and health sciences 0302 clinical medicine medicine Humans Orthopedics and Sports Medicine 030212 general & internal medicine Spinal cord injury Spinal Cord Injuries Publishing Clinical Trials as Topic 030222 orthopedics business.industry Study Type Rehabilitation Significant difference Publication bias medicine.disease Spinal cord United States Clinical trial medicine.anatomical_structure Emergency medicine Physical therapy business
Zdroj:	Journal of Back and Musculoskeletal Rehabilitation. 31:45-48
ISSN:	1878-6324 1053-8127
Popis:	Objective/background Treatment options for spinal cord injuries are currently limited, but multiple clinical trials are underway for a variety of interventions, drugs, and devices. The Food and Drug Administration website www.ClinicalTrials.gov catalogues these trials and includes information on the status of the trial, date of initiation and completion, source of funding, and region. This investigation assesses the factors associated with publication and the publication rate of spinal cord injury trials. Design Retrospective analysis of publically available data on www.ClinicalTrials.gov. Methods The www.ClinicalTrials.gov was queried for all trials on patients with spinal cord injury, and these trials were assessed for status, type of intervention, source of funding, and region. Multiple literature searches were performed on all completed trials to determine publication status. Results There were 626 studies identified concerning the treatment of patients with spinal cord injury, of which 250 (39.9%) were completed. Of these, only 119 (47.6%) were published. There was no significant difference in the rate of publication between regions (p> 0.16) or by study type (p> 0.29). However, trials that were funded by the NIH were more likely to be published than trials funded by industry (p= 0.01). Conclusion The current publication rate of spinal cord injury trials is only 47.6%, though this rate is similar to the publication rate for trials in other fields. NIH-funded trials are significantly more likely to become published than industry-funded trials, which could indicate that some trials remain unpublished due to undesirable results. However, it is also likely that many trials on spinal cord injury yield negative results, as treatments are often ineffective.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ac80729aa86e80651975e54c01737f https://doi.org/10.3233/bmr-169628 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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