The Gut Axis Involvement in Heart Failure
| Autor: | Max Wong, Toru Suzuki, Muhammad Zubair Israr, Andrea Salzano, Shabana Cassambai, Yoshiyuki Yazaki, Dennis Bernieh |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Poor prognosis business.industry Trimethylamine Trimethylamine N-oxide Gastrointestinal system General Medicine 030204 cardiovascular system & hematology medicine.disease Pathophysiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology chemistry Heart failure Internal medicine Medicine Choline 030212 general & internal medicine Carnitine business Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | Cardiology Clinics. 40:161-169 |
| ISSN: | 0733-8651 |
| DOI: | 10.1016/j.ccl.2021.12.004 |
| Popis: | A novel pathophysiological model of interest is the association between heart failure (HF) and the gastrointestinal system, the 'gut hypothesis'. The choline and carnitine metabolic by-product, Trimethylamine N-oxide (TMAO) is one of the more prominent molecules associated with the link between HF and the gut. Indeed, TMAO levels are increased in HF populations and higher TMAO levels are associated with poor prognosis, whereas low TMAO levels either at baseline/follow up confer better prognosis. Considering that TMAO levels seem not to be affected by guideline-HF treatment, this model could represent a novel and independent therapeutic target for HF. |
| Databáze: | OpenAIRE |
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