Longitudinal Sodium MRI of Multiple Sclerosis Lesions: Is there Added Value of Sodium Inversion Recovery MRI

Autor: Manuel Schmidt, Julius Wegmann, Peter Linz, Tobias Engelhorn, Veit Rothhammer, Arnd Doerfler, Angelika Mennecke, Konstantin Huhn, Tobias Wilferth, Armin M. Nagel, Felix Eisenhut, Ralf A. Linker
Rok vydání: 2021
Předmět:
Zdroj: Journal of Magnetic Resonance Imaging. 55:140-151
ISSN: 1522-2586
1053-1807
DOI: 10.1002/jmri.27832
Popis: BACKGROUND Sodium enhancement has been demonstrated in multiple sclerosis (MS) lesions. PURPOSE To investigate sodium MRI with and without an inversion recovery pulse in acute MS lesions in an MS relapse and during recovery. STUDY TYPE Prospective. SUBJECTS Twenty-nine relapsing-remitting MS patients with an acute relapse were included. FIELD STRENGTH/SEQUENCE A 3D density-adapted radial sodium sequence at 3 T using a dual-tuned (23 Na/1 H) head coil. ASSESSMENT Full-brain images of the tissue sodium concentration (TSC1, n = 29) and a sodium inversion recovery sequence (SIR1, n = 20) at the beginning of the anti-inflammatory therapy and on medium-term follow-up visits (days 27-99, n = 12 [TSC], n = 5 [SIR]) were measured. Regions of interest (RoIs) with contrast enhancement (T1 CE+) and without change in T1-weighted imaging (FL + T1n) were normalized (nTSC and nSIR). To gain insight on the origin of the TSC enhancement at time point 1, it is investigated whether the nTSC enhancement of the lesions is accompanied by a change of the respective nSIR. Potential prognostic value of nSIR1 is examined referring to the nTSC progression. STATISTICAL TESTS: nTSC and nSIR were compared regarding the type of lesion and the time point using a one-way ANOVA. Pearson's correlation coefficient was calculated for nTSC over nSIR and for nTSC1-nTSC2 over nSIR1. A P-value
Databáze: OpenAIRE