Longitudinal Sodium MRI of Multiple Sclerosis Lesions: Is there Added Value of Sodium Inversion Recovery MRI
Autor: | Manuel Schmidt, Julius Wegmann, Peter Linz, Tobias Engelhorn, Veit Rothhammer, Arnd Doerfler, Angelika Mennecke, Konstantin Huhn, Tobias Wilferth, Armin M. Nagel, Felix Eisenhut, Ralf A. Linker |
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Rok vydání: | 2021 |
Předmět: |
Multiple Sclerosis
business.industry Pulse (signal processing) Multiple sclerosis Sodium chemistry.chemical_element medicine.disease Magnetic Resonance Imaging Lesion White matter medicine.anatomical_structure chemistry Sodium MRI Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Analysis of variance Stage (cooking) medicine.symptom business Nuclear medicine |
Zdroj: | Journal of Magnetic Resonance Imaging. 55:140-151 |
ISSN: | 1522-2586 1053-1807 |
DOI: | 10.1002/jmri.27832 |
Popis: | BACKGROUND Sodium enhancement has been demonstrated in multiple sclerosis (MS) lesions. PURPOSE To investigate sodium MRI with and without an inversion recovery pulse in acute MS lesions in an MS relapse and during recovery. STUDY TYPE Prospective. SUBJECTS Twenty-nine relapsing-remitting MS patients with an acute relapse were included. FIELD STRENGTH/SEQUENCE A 3D density-adapted radial sodium sequence at 3 T using a dual-tuned (23 Na/1 H) head coil. ASSESSMENT Full-brain images of the tissue sodium concentration (TSC1, n = 29) and a sodium inversion recovery sequence (SIR1, n = 20) at the beginning of the anti-inflammatory therapy and on medium-term follow-up visits (days 27-99, n = 12 [TSC], n = 5 [SIR]) were measured. Regions of interest (RoIs) with contrast enhancement (T1 CE+) and without change in T1-weighted imaging (FL + T1n) were normalized (nTSC and nSIR). To gain insight on the origin of the TSC enhancement at time point 1, it is investigated whether the nTSC enhancement of the lesions is accompanied by a change of the respective nSIR. Potential prognostic value of nSIR1 is examined referring to the nTSC progression. STATISTICAL TESTS: nTSC and nSIR were compared regarding the type of lesion and the time point using a one-way ANOVA. Pearson's correlation coefficient was calculated for nTSC over nSIR and for nTSC1-nTSC2 over nSIR1. A P-value |
Databáze: | OpenAIRE |
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