Long term methylphenidate exposure and growth in children and adolescents with ADHD. A systematic review and meta-analysis

Autor: Roberta Romaniello, Edmund J.S. Sonuga-Barke, Sara Carucci, Angelico Lampis, Ian C. K. Wong, T. Usala, Hanna Kovshoff, Peter Nagy, Kerstin Konrad, S Inglis, Chris Hollis, C. Balia, Antonella Gagliano, Jan K. Buitelaar, David Coghill, Pietro Panei, Alessandro Zuddas, Peter Garas, Ralf W. Dittmann, Elizabeth B. Liddle, Suzanne McCarthy, Marina Danckaerts, Tobias Banaschewski
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Pediatrics
medicine.medical_specialty
puberty
Adolescent
Cognitive Neuroscience
growth
Treatment outcome
methylphenidate
Standard score
Body weight
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Pharmacotherapy
130 000 Cognitive Neurology & Memory
medicine
Humans
0501 psychology and cognitive sciences
ddc:610
050102 behavioral science & comparative psychology
Prospective Studies
Prospective cohort study
Adverse effect
Child
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
Methylphenidate
business.industry
05 social sciences
Body Weight
weight
Neuropsychology and Physiological Psychology
Treatment Outcome
Attention Deficit Disorder with Hyperactivity
Meta-analysis
stimulants
Central Nervous System Stimulants
business
030217 neurology & neurosurgery
Attention deficit/hyperactivity disorder (ADHD)
medicine.drug
height
Zdroj: Carucci, S, Balia, C, Gagliano, A, Lampis, A, Buitelaar, J K, Danckaerts, M, Dittmann, R W, Garas, P, Hollis, C, Inglis, S, Konrad, K, Kovshoff, H, Liddle, E B, McCarthy, S, Nagy, P, Panei, P, Romaniello, R, Usala, T, Wong, I C K, Banaschewski, T, Sonuga-Barke, E, Coghill, D, Zuddas, A & the ADDUCE Consortium 2021, ' Long term methylphenidate exposure and growth in children and adolescents with ADHD. A systematic review and meta-analysis ', Neuroscience and Biobehavioral Reviews, vol. 120, pp. 509-525 . https://doi.org/10.1016/j.neubiorev.2020.09.031
Neuroscience & biobehavioral reviews 120, 509-525 (2021). doi:10.1016/j.neubiorev.2020.09.031
Neuroscience and Biobehavioral Reviews, 120, 509-525
Neuroscience and Biobehavioral Reviews, 120, pp. 509-525
ISSN: 0149-7634
DOI: 10.1016/j.neubiorev.2020.09.031
Popis: Contains fulltext : 231767.pdf (Publisher’s version ) (Closed access) BACKGROUND: Methylphenidate (MPH) is an efficacious treatment for ADHD but concerns have been raised about potential adverse effects of extended treatment on growth. OBJECTIVES: To systematically review the literature, up to December 2018, conducting a meta-analysis of association of long-term (> six months) MPH exposure with height, weight and timing of puberty. RESULTS: Eighteen studies (ADHD n = 4868) were included in the meta-analysis. MPH was associated with consistent statistically significant pre-post difference for both height (SMD = 0.27, 95% CI 0.16-0.38, p < 0.0001) and weight (SMD = 0.33, 95% CI 0.22-0.44, p < 0.0001) Z scores, with prominent impact on weight during the first 12 months and on height within the first 24-30 months. No significant effects of dose, formulation, age and drug-naïve condition as clinical moderators were found. Data on timing of puberty are currently limited. CONCLUSIONS: Long-term treatment with MPH can result in reduction in height and weight. However, effect sizes are small with possible minimal clinical impact. Long-term prospective studies may help to clarify the underlying biological drivers and specific mediators and moderators.
Databáze: OpenAIRE
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