Cohort study of familial viral hepatitis and risks of paediatric cancers
| Autor: | Julia E Heck, Chia-Kai Wu, Xiwen Huang, Kara W Chew, Myron Tong, Noah Federman, Beate Ritz, Onyebuchi A Arah, Chung-Yi Li, Fei Yu, Jorn Olsen, Johnni Hansen, Pei-Chen Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Hepatoblastoma Hepatitis Viral Human Epidemiology Chronic Liver Disease and Cirrhosis Infectious Disease Hepatitis Hepatitis - B Cohort Studies Rare Diseases Hepatitis - C Risk Factors 2.1 Biological and endogenous factors 2.2 Factors relating to the physical environment Humans childhood-cancer epidemiology Viral hepatitis b Aetiology hepatitis c Child Cancer Pediatric Liver Disease non-Hodgkin lymphoma Statistics Liver Neoplasms General Medicine hepatoblastoma Hepatitis C digestive system diseases Emerging Infectious Diseases Infectious Diseases Case-Control Studies Public Health and Health Services pregnancy Digestive Diseases Infection Human |
| Zdroj: | Int J Epidemiol Heck, J E, Wu, C-K, Huang, X, Chew, K W, Tong, M, Federman, N, Ritz, B, Arah, O A, Li, C-Y, Yu, F, Olsen, J, Hansen, J & Lee, P-C 2022, ' Cohort study of familial viral hepatitis and risks of paediatric cancers ', International Journal of Epidemiology, vol. 51, no. 2, pp. 448-457 . https://doi.org/10.1093/ije/dyab262 International journal of epidemiology, vol 51, iss 2 |
| Popis: | BackgroundAlthough viral hepatitis causes paediatric hepatocellular carcinoma and hepatic and extrahepatic cancers in adults, there are few epidemiologic studies on paediatric-cancer risks from parental viral hepatitis. In a nationwide study in a viral hepatitis endemic region and with confirmation in another population-based sample, we examined associations between parental hepatitis B (HBV) and C (HCV) infections and risks of cancers in offspring.MethodsWe included all children born in Taiwan in 2004–2014 (N = 2 079 037) with 2160 cancer cases ascertained from the Cancer Registry. We estimated risks for paediatric cancers using Cox proportional-hazard regressions. We checked these associations in a nationwide case–control study in Denmark (6422 cases, 160 522 controls).ResultsIn Taiwan, paternal HBV was related to child’s hepatoblastoma [hazard ratio (HR) = 1.77, 95% confidence interval (CI) = 1.05, 2.97] when identified at any time in the medical record, and when analyses were limited to hepatitis diagnoses occurring before the child’s birth, risks increased (HR = 2.08, 95% CI = 1.13–3.80). Paternal HCV was related to child’s non-Hodgkin lymphoma (HR = 2.06, 95% CI = 1.13–3.74). Maternal HCV was weakly related to increased risks of all childhood cancers [all types combined; HR = 1.45, 95% CI = 0.95–2.22]. The population-attributable fraction of hepatoblastoma for maternal, paternal and child HBV was 2.6%, 6.8% and 2.8%, respectively.ConclusionsParental HBV and HCV may be risk factors for hepatic and non-hepatic cancers in children. If associations are causal, then parental screening and treatment with antivirals may prevent some paediatric cancers. |
| Databáze: | OpenAIRE |
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