Eosinophil Infiltrates in Pilocytic Astrocytomas of Children and Young Adults
| Autor: | Jian-Qiang Lu, Beverly Wilson, Vivek Mehta, Omid Rashidipour, Andrew S. Jack, Jeffrey A. Pugh |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Central nervous system Disease Astrocytoma Central Nervous System Neoplasms Young Adult Immune system Antigen medicine Humans Eosinophilia Young adult Child Aged business.industry Infant General Medicine Middle Aged Eosinophil medicine.disease Eosinophils medicine.anatomical_structure Neurology Child Preschool Female Neurology (clinical) medicine.symptom business Infiltration (medical) |
| Zdroj: | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 41:632-637 |
| ISSN: | 2057-0155 0317-1671 |
| Popis: | ObjectiveEosinophils may affect each stage of tumour development. Many studies have suggested that tumour-associated tissue eosinophilia (TATE) is associated with favourable prognosis in some malignant tumours. However, only a few studies exist on TATE in central nervous system (CNS) tumours. Our recent study exhibited eosinophils in atypical teratoid/rhabdoid tumours (AT/RTs), pediatric malignant CNS tumours with divergent differentiation. This study examines eosinophils in pilocytic astrocytomas (PAs).MethodsThe study included 44 consecutive cases of patients with PAs and no concurrent CNS inflammatory disease.ResultsWe found eosinophils in 19 (43%) of 44 PAs (patient age range, 0.5-72 years). Eosinophils were intratumoural and clearly distinguishable. The density of eosinophils was rare to focally scattered. PAs containing eosinophils were located throughout the CNS. Furthermore, eosinophilic infiltration was identified in 18 (62%) of 29 pediatric (age range, 0.5-18 years) PAs but only 1 (7%) of 15 (pConclusionsThese results suggest that eosinophils are common in pediatric PAs but rare in adult PAs. This difference is probably related to the developing immune system and different tumour-specific antigens in children. TATE may play a functional role in the development of pediatric PAs, as well as some other pediatric CNS tumours such as AT/RTs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|