Differential Impairment of Vascular Reactivity of Small Pulmonary and Systemic Arteries in Hyperdynamic Sepsis
| Autor: | David G. McCormack, Claudio Martin, William J. Sibbald, Nigel A. M. Paterson, Asma Yaghi |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Cardiac output Pathology Hemodynamics Femoral artery Pulmonary Artery Rats Sprague-Dawley Renal Artery Celiac Artery Internal medicine medicine.artery Catheterization Peripheral Animals Medicine Renal artery Hyperdynamic sepsis Cecum Ligation Dose-Response Relationship Drug business.industry Respiratory disease Blood flow medicine.disease Shock Septic Rats Femoral Artery Disease Models Animal Mean blood pressure Intestinal Perforation Cardiology Vascular Resistance business |
| Zdroj: | American Review of Respiratory Disease. 148:164-172 |
| ISSN: | 0003-0805 |
| DOI: | 10.1164/ajrccm/148.1.164 |
| Popis: | We postulated that the redistribution of organ blood flow that occurs in hyperdynamic sepsis is secondary to organ-specific alterations in vascular reactivity. Chronically instrumented rats were randomized to cecal ligation and perforation (CLP) (n = 12) or to a control procedure (n = 11). Cardiac output increased from 107 +/- 23 ml/min at baseline to 152 +/- 32 ml/min at 24 h after CLP (p = 0.037 versus control values). Mean blood pressure did not change in either group. Small arterial ring segment (100- to 200-microns effective lumen radius) from the pulmonary, renal, celiac, and femora arteries were obtained for determination of in vitro responsiveness. Maximal contractile responses to three receptor-operated contractile agonists were significantly depressed in the pulmonary (p = 0.001) and the celiac (p = 0.001) arteries from CLP versus control rats. The renal artery showed a trend toward decreased responsiveness (p = 0.049), but not difference was seen in the femoral artery (p = 0.172). EC50 values were unchanged. A similar, but less marked, pattern was observed for KCI-induced contractions in that depressed responses were noted in the pulmonary (p = 0.045) and celiac (p = 0.064) arteries. Vasodilator responses to acetylcholine were normal in all vessels. Nitroprusside relaxant responses were enhanced in the pulmonary artery (p = 0.022), but they were normal in the other vessels. We conclude that hyperdynamic, normotensive sepsis is associated with an organ-specific alteration of vascular smooth muscle function that particularly affects receptor-operated contractile responses. The differential expression of this altered vascular responsiveness between organs may contribute to the observed variance in regional blood flows in sepsis. |
| Databáze: | OpenAIRE |
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