Efficacy and safety of regimens used for the treatment of multicentric Castleman disease: A systematic review

Autor: Mohammad Ebad Ur Rehman, Asmi Chattaraj, Karun Neupane, Abdul Rafae, Sajeel Saeed, Jawad Basit, Atif Ibrahim, Jack Khouri, Sudipto Mukherjee, Faiz Anwer
Rok vydání: 2022
Předmět:
Zdroj: European Journal of Haematology. 109:309-320
ISSN: 1600-0609
0902-4441
DOI: 10.1111/ejh.13823
Popis: Treatment options for multicentric Castleman disease (MCD) remain limited. The only FDA-approved drug is siltuximab for idiopathic MCD (iMCD), but the response rate with siltuximab is less than 50%. We performed a systematic review to examine the efficacy and safety of various regimens used for the treatment of MCD.A database search on PubMed, Embase, Cochrane, Web of Science, and Clinicaltrials.gov using the terms "Castleman disease," "treatment outcome," and "patient safety" was done.Results from a randomized controlled trial and an extension study highlighted the efficacy and long-term safety of siltuximab for iMCD; other trials showed tocilizumab to be a suitable alternative. A recent trial reported high response rates with thalidomide in iMCD patients. Promising results were reported for bortezomib in relapsed/ refractory MCD. For human herpesvirus-8 (HHV8)-associated MCD, rituximab along with doxorubicin therapy followed by maintenance with zidovudine and valganciclovir is the most effective therapy. A single-arm trial has highlighted the potential role of tocilizumab in HHV8-MCD. Data for these regimens are limited and mostly comprise nonrandomized trials. Further research on emerging agents could have a major impact on the treatment of this rare disease.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje