The Future of Surfactant Therapy for Patients with Acute Lung Injury – New Requirements and New Surfactants
| Autor: | Roger G. Spragg |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Lung Diseases
medicine.medical_specialty Drug Industry medicine.medical_treatment Lung injury Surfactant therapy Infant Newborn Diseases Pulmonary surfactant Animals Humans Medicine In patient Intensive care medicine Mechanical ventilation Respiratory Distress Syndrome Newborn Lung business.industry Infant Newborn Pulmonary Surfactants respiratory system respiratory tract diseases medicine.anatomical_structure Animals Newborn Anesthesia Acute Disease Pediatrics Perinatology and Child Health Neonatology business Developmental Biology |
| Zdroj: | Neonatology. 81:20-24 |
| ISSN: | 1661-7819 1661-7800 |
| DOI: | 10.1159/000056767 |
| Popis: | New requirements must be considered when designing trials of new lung surfactants for patients with acute lung injury (ALI). Radiographic inclusion criteria must be carefully applied if they are to generate reproducible patient groups. Strategies for ventilation are now known to significantly affect outcome and also must be clearly defined and applied. Similar mortality rates in patients with different degrees of gas exchange and radiographic abnormalities suggest that prior clinical distinctions should be re-examined. Current trials of surfactant therapy for ALI are examining the efficacy of a natural surfactant, a surfactant containing recombinant SP-C and a surfactant based on an SP-B-like peptide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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