High levels of fasting glucose and glycosylated hemoglobin values are associated with hyperfiltration in a Spanish prediabetes cohort. The PREDAPS Study
Autor: | Gabriel Coll de Tuero, Antonio Rodriguez-Poncelas, Josep Franch-Nadal, Margarita Alonso-Fernández, Antonio José Ortiz Ruiz, Teresa Mur-Marti, Carolina Giráldez-García, Manel Mata-Cases, Enrique Regidor |
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Rok vydání: | 2019 |
Předmět: |
Blood Glucose
Male endocrine system diseases Physiology Kidneys -- Diseases 030232 urology & nephrology Blood Pressure Biochemistry Vascular Medicine Gastroenterology Cohort Studies Endocrinology 0302 clinical medicine Risk Factors Chronic Kidney Disease Odds Ratio Diabetes diagnosis and management Medicine Prediabetes Prospective cohort study Diabetis Multidisciplinary Diabetes Fasting Middle Aged Nephrology Hypertension Cohort Blood pressure Hipertensió Female Anatomy Glomerular Filtration Rate Research Article Cohort study Adult medicine.medical_specialty HbA1c Ronyons -- Malalties Endocrine Disorders Science Renal function 030209 endocrinology & metabolism Pressió sanguínia Prediabetic State 03 medical and health sciences Diabetes mellitus Internal medicine Diabetes Mellitus Humans Obesity Hemoglobin Renal Insufficiency Chronic Aged Nutrition Glycated Hemoglobin Medicine and health sciences Renal Physiology Biology and life sciences business.industry Proteins nutritional and metabolic diseases Kidneys Renal System Odds ratio medicine.disease Diagnostic medicine Diet Spain Metabolic Disorders business |
Zdroj: | PLoS ONE r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname Scopus RUO. Repositorio Institucional de la Universidad de Oviedo PLoS ONE, 2019, vol. 14, núm. 9, p. e0222848 Articles publicats (D-CM) DUGiDocs – Universitat de Girona PLoS ONE, Vol 14, Iss 9, p e0222848 (2019) |
ISSN: | 1932-6203 |
Popis: | This study aimed to investigate whether different levels of fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) in prediabetes are associated with hyperfiltration. Methods A prospective cohort of 2,022 individuals aged 30–74 years took part in the PREDAPS Study. One cohort of 1,184 participants with prediabetes and another cohort of 838 participants with normal FPG and normal HbA1c were followed for 5 years. Hyperfiltration was defined as an estimated glomerular filtration rate (eGFR) above the age- and gender-specific 95th percentile for healthy control participants, while hypofiltration was defined as an eGFR below the 5th percentile. The prevalence of hyperfiltration was compared for different levels of prediabetes: level 1 of prediabetes: FPG |
Databáze: | OpenAIRE |
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