| Autor: |
Qingde Zhou, Jianxiang Gong, Jianing Bi, Xuanxin Yang, Li Zhang, Chao Lu, Lijia Li, Min Chen, Jianqiu Cai, Rongshuai Yang, Xiaokun Li, Zhiming Li, Xiaojie Wang |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
The Journal of investigative dermatology. 142(7) |
| ISSN: |
1523-1747 |
| Popis: |
Hypertrophic scar is a common complication of burns, skin trauma, and postoperative trauma, which involves excessive proliferation of fibroblasts and accumulation of a large amount of disorganized collagen fibers and extracellular matrix. KGF-2 plays important roles in the regulation of cellular homeostasis and wound healing. In this study, we investigated the effect and underlying mechanism of KGF-2 on scar formation after wound healing both in vitro and in vivo. We show that KGF-2 attenuates mechanical stress-induced scar formation while promoting wound healing. Mechanistically, KGF-2 inhibits STAP-2 expression and signal transducer and activator of transcription 3 activation, leading to significantly reduced collagen I and collagen III levels. Our results provide an insight into the role of KGF-2 in wound healing and scar formation and the therapeutic potential for reducing scarring while promoting wound healing. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
