Utility of c-erbB-2 expression in tissue and sera of ovarian cancer patients
| Autor: | Nejat Dalay, Kenan Dolapcioglu, Hulya Yazici, Faruk Buyru |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Cancer Research C erbb 2 animal structures Receptor ErbB-2 Healthy tissue Ovary Biology Elevated serum Gene expression medicine Biomarkers Tumor Humans skin and connective tissue diseases neoplasms Gene Aged Ovarian Neoplasms General Medicine Middle Aged medicine.disease Tumor tissue medicine.anatomical_structure Oncology Cancer research Female Ovarian cancer |
| Zdroj: | Cancer investigation. 18(2) |
| ISSN: | 0735-7907 |
| Popis: | In this study, expression of the c-erbB-2 gene in tumors and healthy tissue of patients with ovarian cancer was investigated. Serum c-erbB-2 protein levels were also determined. Elevated serum values were observed in 45% of patients. c-erbB-2 protein levels in the tumors were significantly higher than in healthy tissue. Overexpression of the protein was observed in 60% of patients. However, no association was found behveen the clinical variables and tumor c-erbB-2 expression. This is the first study in the literature investigating the c-erbB-2 oncoprotein levels in the normal and tumor tissue. We conclude that the role of the c-erbB-2 gene in ovarian cancer warrants further studies. |
| Databáze: | OpenAIRE |
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