Intra-osseous basivertebral nerve radiofrequency ablation (BVA) for the treatment of vertebrogenic chronic low back pain
Autor: | Giovanni D'Agostino, Fausto Ventura, Gennaro D'Anna, Hosam Al Qatami, Aldo Eros De Vivo, Ines Gil, Luigi Manfrè |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Percutaneous Visual analogue scale Radiofrequency ablation medicine.medical_treatment 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences 0302 clinical medicine law medicine Humans Radiology Nuclear Medicine and imaging Local anesthesia Prospective Studies Nerve Tissue Radiofrequency Ablation business.industry Minimal clinically important difference Ablation Low back pain Oswestry Disability Index Surgery Treatment Outcome Neurology (clinical) Chronic Pain medicine.symptom Cardiology and Cardiovascular Medicine business Low Back Pain 030217 neurology & neurosurgery |
Zdroj: | Neuroradiology. 63:809-815 |
ISSN: | 1432-1920 0028-3940 |
DOI: | 10.1007/s00234-020-02577-8 |
Popis: | Prospective experimental uncontrolled trial. Vertebrogenic pain is a frequently underestimated cause of chronic low back pain (LBP). Vertebral endplate degeneration, characterized by cortical bone damage and subchondral bone inflammatory reaction, is a significant source of LBP, the responsible of the pain transmission being the Basivertebral Nerve (BVN). Radiofrequency ablation of the BVN (BVA) leads to thermal injury of nerve tissue and interruption of the of chronic vertebrogenic pain transmission. The aim of this study is to evaluate the effectiveness, in terms of pain and disability reduction, of percutaneous (BVA) in treating patients affected by vertebrogenic chronic LBP. Moreover, as a secondary endpoint, the purpose is to assess the feasibility and safety of a percutaneous CT-guided technique. We performed percutaneous CT-guided BVN ablation in 56 consecutive patients presenting with vertebrogenic chronic LBP in local anesthesia using an articulating bipolar radiofrequency electrode (STAR™ Tumor Ablation System Merit). A 1-month follow-up MRI was performed to evaluate the ablation area in order to assess the target success of the procedure. A 3-month follow-up CT study was performed to evaluate bone mineral density in order to exclude structural bone abnormalities that might have been induced by the treatment. Pre- and post-procedure pain and disability levels were measured using the visual analogue scale (VAS) and Oswestry Disability Index (ODI). A 2-cm improvement threshold was set as clinical success for the VAS score and a 10-point improvement threshold was set as clinical success for the ODI score. At 3- and 12-month follow-up, VAS and ODI scores decreased significantly compared to baseline. Clinical success was reached in 54/56 patients (96.5%) for pain and 54/56 patients (96.5%) for disability, exceeding significantly the MCID. CT-assisted targeting of the ablation zone was determined successful in 100% of patients. Mean operative time was 32 min. No immediate or delayed complications were detected. Percutaneous CT-guided intra-osseous BVA seems to be a safe, fast, and powerful technique for pain relief in patients with vertebrogenic chronic LBP, when the selection of patients is based on a multidisciplinary approach including both conventional Diagnostic Radiology and Nuclear Medicine imaging. |
Databáze: | OpenAIRE |
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