C-reactive protein/albumin ratio is a prognostic indicator in Asians with pancreatic cancers: A meta-analysis
| Autor: | Ke-zhi Li, Zhi-qing Liang, Yan-jun Fu, Ji-hong Bai |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty Subgroup analysis 03 medical and health sciences 0302 clinical medicine Asian People Predictive Value of Tests Pancreatic cancer Internal medicine medicine Humans C-reactive protein/albumin ratio 030212 general & internal medicine pancreatic cancers Serum Albumin biology business.industry Hazard ratio C-reactive protein General Medicine Publication bias medicine.disease Prognosis prognosis value Confidence interval Pancreatic Neoplasms C-Reactive Protein 030220 oncology & carcinogenesis Predictive value of tests Meta-analysis biology.protein business Systematic Review and Meta-Analysis Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Background: The prognostic value of C-reactive protein/albumin ratio (CAR) in pancreatic cancer remains controversial. This study aimed to determine the potential role of CAR as a prognostic indicator in pancreatic cancer. Methods: A comprehensive literature search up to December 2018 was conducted using PubMed, Web of Science, and other databases. The hazard ratio (HR) with 95% confidence interval (CI) was employed to quantitatively assess CAR as a prognostic indicator in patients with pancreatic cancer. Results: Eleven studies with 2047 pancreatic cancer patients were selected for the analysis. Ten out of 11 studies included only Asian patients. The pooled results showed that a higher CAR value was significantly associated with a poor overall survival of pancreatic cancer patients (random-effects model: HR = 1.86; 95% CI = 1.53–2.26). Sensitivity analysis indicated the stability of the overall pooled results. Subgroup analysis and meta-regression analysis revealed that the country under study, cut-off value of CAR, treatment of patients, and the period of follow-up did not affect the prognostic value of CAR in pancreatic cancer patients (P > .05). No publication bias was noted across the studies (P = .933). Conclusion: This meta-analysis suggests that CAR is associated with the survival of pancreatic cancer patients of Asian ethnicity, and a higher CAR may be a potential prognostic indicator in pancreatic cancers. |
| Databáze: | OpenAIRE |
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