G-CSF prevents cerebral infarction and maintain muscle strength in experimental model of ischemic stroke
| Autor: | Brenna Lepaus Monteiro, Brunelli da Ros Peruch, Marco Cesar Cunegundes Guimarães, Breno Valentim Nogueira, Lohayne Simões Barbosa, Rayssa Florentina Scárdua, Manoel Ramos Penha, Rafaela Aires |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Treated group Tetrazolium chloride business.industry Experimental model Cerebral infarction General Medicine medicine.disease General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound chemistry Internal medicine medicine.artery Poster Presentation Ischemic stroke Cardiology Muscle strength Medicine Common carotid artery business Stroke Biomedical engineering |
| Zdroj: | BMC Proceedings |
| ISSN: | 1753-6561 |
| DOI: | 10.1186/1753-6561-8-s4-p42 |
| Popis: | 011/2011). The measurement of the strength of the mice was performed in the pre and post surgery through software coupled to a force transducer. The quantification of the area of cerebral infarction using 2,3,5-triphenil tetrazolium chloride was established by morphometric analysis using Image J program (NIH). The data are presented as means ± SEM. Statistical analysis was performed using Student’s t test for comparison of groups using the software Prism ® 5.0 (GraphPad, San Diego, CA, USA). p values < 0.05 were considered to be statistically significant. Results and conclusions A significant increase in the number of circulating leukocytes in the animals treated with G-CSF (= AVE + vehicle 2,550 ± 283/mm3 vs. G-CSF + AVE = 15,650 ± 1,294/ mm3, p < 0.01) was observed. The strength after surgery was significantly higher (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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