Reduced-intensity umbilical cord blood transplant for older adult patients
| Autor: | William V. Esler, Phillip O. Periman, Mary Townsend, Seah H. Lim, David Beggs, Yana Zhang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Graft vs Host Disease Umbilical cord fluids and secretions Cell transplantation Older patients Cell dose Female patient medicine Humans Aged Transplantation Adult patients business.industry Graft Survival Age Factors Reduced intensity Hematology Middle Aged medicine.disease Comorbidity Surgery Treatment Outcome medicine.anatomical_structure embryonic structures Cord Blood Stem Cell Transplantation business |
| Zdroj: | Bone Marrow Transplantation. 42:685-686 |
| ISSN: | 1476-5365 0268-3369 |
| DOI: | 10.1038/bmt.2008.225 |
| Popis: | recently addressed the role of unrelated UCBtransplantsforolderpatientsandreportedthattheresultsof UCB transplants carried out in 43 adult patients olderthan 55yearswerecomparabletothoseobtainedfrom 47matched related donor transplants.The 3-year probabilityof progression-free survival was 34% in UCB transplantscompared with30%in matched related donor transplantsand suggested that HLA-mismatched UCB could be analternative graft source for older patients who need atransplantbutdonothaveamatchedrelateddonor.We have carried out an analysis of the results of olderpatients who have undergone reduced-intensity mis-matched UCB transplant in our program. Nine olderpatients, median age 60 years (range 48–77 years) havereceivedmismatchedUCB;78%ofthesepatientsreceivedtwo UCB units to optimize the cell dose. Two patientsreceived one HLA-mismatched, four patients two HLA-mismatched and three patients three HLA-mismatchedgrafts. Clinical characteristics of these patients and theinfused UCB units are shown in Table 1. There were sixmale patients and three female patients. Their medianweight was 72kg (range 60–98kg). Eight patients hadAML,twowithprimaryrefractoryAML,andonepatienthadadvancedrefractoryCLL.Fourpatientshadhemato-poietic cell transplantation comorbidity scores of X2before transplant. |
| Databáze: | OpenAIRE |
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