Correction: Duncan, K.R., Suzuki, Y.J. Vitamin E Nicotinate. Antioxidants 2017, 6, 20
| Autor: | Yuichiro J. Suzuki, Kimbell R Duncan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
tocopheryl nicotinate Physiology Stereochemistry Published Erratum Vitamin E medicine.medical_treatment lcsh:RM1-950 Clinical Biochemistry Correction Review Cell Biology Biochemistry vitamin E nicotinate 03 medical and health sciences n/a lcsh:Therapeutics. Pharmacology 030104 developmental biology tocopherol nicotinate medicine Molecular Biology Mathematics |
| Zdroj: | Antioxidants Antioxidants, Vol 7, Iss 5, p 64 (2018) |
| ISSN: | 2076-3921 |
| DOI: | 10.3390/antiox7050064 |
| Popis: | Vitamin E refers to a family of compounds that function as lipid-soluble antioxidants capable of preventing lipid peroxidation. Naturally occurring forms of vitamin E include tocopherols and tocotrienols. Vitamin E in dietary supplements and fortified foods is often an esterified form of α-tocopherol, the most common esters being acetate and succinate. The vitamin E esters are hydrolyzed and converted into free α-tocopherol prior to absorption in the intestinal tract. Because its functions are relevant to many chronic diseases, vitamin E has been extensively studied in respect to a variety of diseases as well as cosmetic applications. The forms of vitamin E most studied are natural α-tocopherol and the esters α-tocopheryl acetate and α-tocopheryl succinate. A small number of studies include or focus on another ester form, α-tocopheryl nicotinate, an ester of vitamin E and niacin. Some of these studies raise the possibility of differences in metabolism and in efficacy between vitamin E nicotinate and other forms of vitamin E. Recently, through metabolomics studies, we identified that α-tocopheryl nicotinate occurs endogenously in the heart and that its level is dramatically decreased in heart failure, indicating the possible biological importance of this vitamin E ester. Since knowledge about vitamin E nicotinate is not readily available in the literature, the purpose of this review is to summarize and evaluate published reports, specifically with respect to α-tocopheryl nicotinate with an emphasis on the differences from natural α-tocopherol or α-tocopheryl acetate. |
| Databáze: | OpenAIRE |
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