Degree of crosslinking in β-cyclodextrin-based nanosponges and their effect on piperine encapsulation
| Autor: | Loong-Tak Lim, Aldo Rolleri, Marcela Quilaqueo, Jeyson Hermosilla, Juan Guineo-Alvarado, Mónica Rubilar, Camila Medina, Sofía González |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Polyunsaturated Alkamides
Drug Compounding 01 natural sciences Analytical Chemistry Crystallinity chemistry.chemical_compound 0404 agricultural biotechnology Alkaloids Piperidines Nanosponges Benzodioxoles Microwaves chemistry.chemical_classification Aqueous solution Cyclodextrin Chemistry Alkaloid 010401 analytical chemistry beta-Cyclodextrins 04 agricultural and veterinary sciences General Medicine Polymer 040401 food science 0104 chemical sciences Nanostructures Diphenyl carbonate Solubility Piperine Piper nigrum Food Science Nuclear chemistry |
| Zdroj: | Food chemistry. 340 |
| ISSN: | 1873-7072 |
| Popis: | Piperine (PIP) is an alkaloid which is potent as a therapeutic agent. However, its applications are restricted by its poor water solubility. Nanosponges (NS) derived from polymers are versatile carriers for poor water-soluble substances. The aim of this work was to synthesize β-cyclodextrin NS, by microwave-assisted fusion, for the encapsulation of PIP. Different formulations of NS were synthesized by varying the molar ratio of β-cyclodextrin:diphenyl carbonate (β-CD:DPC; 1:2, 1:6 and 1:10). NS specimens derived from 1:2, 1:6 and 1:10 β-CD:DPC molar ratios exhibited degree of substitution values of 0.345, 0.629 and 0.878, respectively. The crystallinity of NS was enhanced by increasing diphenyl carbonate concentration. A high degree of crosslinking in the NS increased the loading efficiency due to increased surface area available for bioactive inclusion. This study demonstrated the feasibility of synthesizing NS derived from β-cyclodextrin of high crystallinity for the encapsulation of PIP at high loading capacity. |
| Databáze: | OpenAIRE |
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