Quality of evidence of the efficacy of therapeutic interventions on patient-important outcomes in Cochrane's systematic reviews’ abstracts: A survey
| Autor: | Nemat Jaafari, Hélène Vaillant-Roussel, Benoit Tudrej, Denis Pouchain, Elodie Tawil, Caroline Huas, Rémy Boussageon, Christine Maynié-François, Florian Naudet |
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| Přispěvatelé: | Collège Universitaire de Médecine Générale [Lyon] (CUMG), Université de Lyon, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Département de Médecine Générale, Université de Poitiers (DMG), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers-Université de Poitiers, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Fondation santé des Etudiants de France, Fondation Santé des Etudiants de France, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Université de Tours (UT), AutomédiCation aCcompagnement Pluriprofessionnel PatienT (ACCePPT), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre de Recherches sur la Cognition et l'Apprentissage (CeRCA), Université de Poitiers-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours, Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Université de Poitiers |
| Rok vydání: | 2021 |
| Předmět: |
Evidence-based medicine
medicine.medical_specialty 030309 nutrition & dietetics education Psychological intervention Placebo 03 medical and health sciences 0302 clinical medicine Intervention (counseling) parasitic diseases Clinical endpoint Medicine Pharmacology (medical) GRADE approach Intensive care medicine 0303 health sciences Cochrane collaboration business.industry [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences 030205 complementary & alternative medicine 3. Good health Quality of evidence Patient-important outcome Systematic review business |
| Zdroj: | Alternative and Complementary Therapies Alternative and Complementary Therapies, 2021, 76 (5), pp.403-408. ⟨10.1016/j.therap.2020.09.004⟩ Alternative and Complementary Therapies, Mary Ann Liebert, 2020, ⟨10.1016/j.therap.2020.09.004⟩ Alternative and Complementary Therapies, Mary Ann Liebert, 2021, 76 (5), pp.403-408. ⟨10.1016/j.therap.2020.09.004⟩ |
| ISSN: | 0040-5957 1076-2809 |
| DOI: | 10.1016/j.therap.2020.09.004 |
| Popis: | International audience; OBJECTIVE: The objective of this study was to evaluate the proportion of therapeutics that have proven their efficacy on patient-important outcomes with a high quality of evidence among Cochrane systematic reviews (SRs). METHODS: We surveyed a random sample of 400 SRs’ abstracts published between September 2012 and December 2015, which compared therapeutic interventions with at least a placebo or no intervention control. The primary endpoint was the proportion of SRs with a statistically significant efficacy on a patient-important outcome and with a high quality of evidence. RESULTS: Among the 400 abstracts surveyed, 32 (8%) found efficacy on a patient-important outcome with a high quality of evidence. Half of the 400 SRs (50.2%) evaluated a pharmacological intervention and 12% of these found efficacy of the intervention on a patient-important outcome with a reported high quality of evidence. CONCLUSION: Based on an analysis of 400 abstracts of SRs from the Cochrane Collaboration, we found that there is a low number of therapeutic interventions which have proven their efficacy on patient-important outcomes with a high quality of evidence. |
| Databáze: | OpenAIRE |
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