von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation
| Autor: | Martine J. Hollestelle, Ebenezer Akrofi Mantey, Srabasti J. Chakravorty, James Bunn, Alister Craig, Alex Osei Yaw Akoto, Jan A. van Mourik, James S. O’Donnell, Cynthia Donkor |
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| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Blood Platelets
Erythrocytes Endothelium Malaria Cerebral ABO Blood-Group System Pathogenesis Endothelial activation Von Willebrand factor hemic and lymphatic diseases von Willebrand Factor parasitic diseases medicine Cell Adhesion Humans Malaria Falciparum Protein Precursors Child biology Endothelial Cells Infant Plasmodium falciparum Hematology biology.organism_classification medicine.disease Endothelial stem cell medicine.anatomical_structure C-Reactive Protein Cerebral Malaria Child Preschool Immunology biology.protein cardiovascular system Endothelium Vascular Malaria |
| Zdroj: | British journal of haematology, 133(5), 562-569. Wiley-Blackwell |
| ISSN: | 0007-1048 |
| Popis: | The pathogenicity of Plasmodium falciparum is thought to relate to the unique ability of infected erythrocytes to adhere to and subsequently activate the vascular endothelium. To study the state of endothelial activation during falciparum malaria, we measured plasma levels of both von Willebrand factor (VWF) and its propeptide, indices of chronic and acute endothelial cell perturbation, respectively. Results were correlated with clinical and biochemical markers of disease severity, including plasma lactate. Our data show that acute endothelial cell activation is a hallmark of malaria in children, indicated by a significant rise in VWF and VWF propeptide. The highest VWF and propeptide levels were seen in cerebral and non-cerebral severe malaria, and associations found between VWF propeptide level and lactate (P < 0.001). Mean VWF propeptide levels (nmol/l) were in cerebral malaria 33.4, non-cerebral severe malaria 26.3, mild malaria 22.1, non-malaria febrile illness 10.2, and controls 10.1. Differences between patient and control groups were highly significant (P < 0.005). Follow-up of 26 cerebral malaria cases showed that levels of VWF propeptide, but not VWF fell by 24 h, following the clinical course of disease and recovery. These novel findings potentially implicate acute, regulated exocytosis of endothelial cell Weibel-Palade bodies in the pathogenesis of Plasmodium falciparum malaria. |
| Databáze: | OpenAIRE |
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