The formation and the strong inhibitory action of 7-keto-cholesterol on cholesterol-7α-hydroxylase activity
| Autor: | Jacques Van Cantfort |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
chemistry.chemical_classification
Carbon Isotopes Cholesterol General Medicine In Vitro Techniques Ketosteroids Tritium Inhibitory postsynaptic potential General Biochemistry Genetics and Molecular Biology In vitro Mixed Function Oxygenases Kinetics chemistry.chemical_compound Cholesterol 7α hydroxylase Enzyme chemistry Biochemistry Microsomes Liver Animals lipids (amino acids peptides and proteins) Chromatography Thin Layer General Pharmacology Toxicology and Pharmaceutics Incubation Hydroxysteroids |
| Zdroj: | Life Sciences. 11:773-780 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(72)90072-0 |
| Popis: | 7-keto-cholesterol is a non-physiological compound usually formed in vitro during the incubation of cholesterol. Experimental data indicates that this substance does not derive from 7α-hydroxycholesterol. Therefore, its formation should not be taken into account in the measurement of cholesterol-7α-hydroxylase activity. However, 7-keto-cholesterol strongly inhibits the activity of this enzyme. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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