Determinants of Health-Related Quality of Life and Physical Performance-Based Components of Frailty in Patients Undergoing Hemodialysis
| Autor: | Manae Harada, Atsuhiko Matsunaga, Ryota Matsuzawa, Cynthia Delgado, Baback Roshanravan, Atsushi Yoshida, Yuta Suzuki, Akira Tamaki, Takaaki Watanabe, Takahiro Shimoda, Shohei Yamamoto |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty medicine.medical_treatment 030232 urology & nephrology Medicine (miscellaneous) Disease Logistic regression Article Odds Cohort Studies 03 medical and health sciences 0302 clinical medicine Quality of life Renal Dialysis Humans Medicine Social determinants of health Aged 030109 nutrition & dietetics Nutrition and Dietetics Frailty Hand Strength business.industry Confounding Middle Aged Physical Functional Performance Confidence interval Nephrology Quality of Life Physical therapy Hemodialysis business |
| Zdroj: | J Ren Nutr |
| ISSN: | 1051-2276 |
| Popis: | OBJECTIVES: Health-related quality of life (HRQoL) measures capture the patient’s experience of the burden of chronic disease and are strongly associated with adverse health-related outcomes across multiple populations. The SF-36 score is the most widely used HRQoL measure among patients with end-stage renal disease (ESRD). Current understanding of determinants of the physical component summary (PCS) and the mental component summary (MCS) and their association with objectively measured physical performance and activity is limited. DESIGN: Cross-sectional study. SETTING AND SUBJECTS: As an index of HRQoL, we prospectively examined the association of SF-36 and its component scores with physical function among 155 incident dialysis patients from the Hemodialysis Center. We investigated associations of HRQoL with the physical performance-based components of the frailty using multivariate linear and logistic regression after adjustment for confounders. PREDICTOR: HRQoL score. MAIN OUTCOME: Impaired physical performance was defined as having either slow usual gait speed or weak handgrip strength based on standardized and validated criteria derived from a large cohort study of older adults. RESULTS: The patients had a mean age of 65 ± 11 years, and 52.3% were male. After adjusting confounders, lower PCS was independently associated with decreased physical performance and reduced physical activity, but MCS was not associated. Among the PCS subscales, only physical functioning 10 (PF-10) was consistently associated with outcomes, and every 1 point increase in PF-10 score was associated with 4% lower odds of impaired physical performance (95%CI: 2 to 7%; P=0.01) after adjustment. CONCLUSIONS: SF-36, especially PF-10, is a valid surrogate that discriminates low physical performance and physical inactivity in the absence of formal physical function testing in patients on hemodialysis. The routine implementation of the PF-10 in clinical care has important clinical implications for medical management and therapeutic decision-making in patients undergoing hemodialysis. |
| Databáze: | OpenAIRE |
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