Association of enlarged perivascular spaces with Aβ and tau deposition in cognitively normal older population
| Autor: | Alzheimer’s Disease Neuroimaging Initiative, Wen-Bin Li, Mingliang Wang, Mengmeng Yu, Yuehua Li, Xiao-Er Wei |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Aging medicine.medical_specialty tau Proteins 03 medical and health sciences 0302 clinical medicine Neuroimaging Internal medicine Centrum semiovale Basal ganglia medicine Humans Perivascular space Aged Aged 80 and over Amyloid beta-Peptides Aniline Compounds medicine.diagnostic_test business.industry General Neuroscience Age Factors Magnetic resonance imaging Odds ratio Magnetic Resonance Imaging Healthy Volunteers Confidence interval 030104 developmental biology medicine.anatomical_structure Positron emission tomography Positron-Emission Tomography Cardiology Ethylene Glycols Female Neurology (clinical) Radiopharmaceuticals Geriatrics and Gerontology business Glymphatic System 030217 neurology & neurosurgery Carbolines Developmental Biology |
| Zdroj: | Neurobiology of Aging. 100:32-38 |
| ISSN: | 0197-4580 |
| Popis: | The relationship between magnetic resonance imaging (MRI)-visible enlarged perivascular spaces (EPVS) and Aβ and tau deposition is poorly investigated in cognitively normal older population. In our study, a total of 106 cognitively normal older subjects from the Alzheimer's Disease Neuroimaging Initiative database were included. All the subjects underwent brain MRI, florbetapir positron emission tomography (PET), and flortaucipir PET examinations. EPVS were rated on MRI using a 5-point scale in the basal ganglia (BG-EPVS) and the centrum semiovale (CSO-EPVS). Our study revealed that 43 subjects had high-degree BG-EPVS (degree >1) and 58 subjects had high-degree CSO-EPVS (degree >1). In logistic regression, high degree of BG-EPVS was associated with age (odds ratio [OR]: 1.08, 95% confidence interval [CI]: 1.01-1.16) and severe deep white matter hyperintensity (OR: 2.67, 95% CI: 1.12-6.35). High degree of CSO-EPVS was associated with flortaucipir PET positivity (OR: 2.24, 95% CI: 1.02-4.93). In conclusion, high degree of CSO-EPVS was associated with tau deposition in the brain, whereas high degree of BG-EPVS was associated with age and severe deep white matter hyperintensity, a marker of small vessel disease. |
| Databáze: | OpenAIRE |
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