The renal excretion of hydrogen ion in uric acid stone formers
| Autor: | M. Zweig, M.D. Johnson, George L.A. From, A. Rapoport, P.O. Crassweller, H. Husdan |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Calcium oxalate Titratable acid Urine urologic and male genital diseases Oxalate Excretion Kidney Calculi chemistry.chemical_compound Endocrinology Ammonia Internal medicine medicine Humans Ammonium Aged Oxalates Autoanalysis Hydrogen-Ion Concentration Middle Aged Uric Acid chemistry Uric acid Ammonium chloride |
| Zdroj: | Metabolism. 16:176-188 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(67)90110-2 |
| Popis: | Renal hydrogen ion excretion was examined in 16 patients with uric acid calculi and in 2 control groups, the first consisting of 16 patients with calcium oxalate calculi and the second, 11 normal subjects. It was found that, both under basal conditions as well as during acid loading with ammonium chloride, patients with uric acid calculi tended to excrete urines of lower pH, lower ammonium and higher titratable acid than those forming oxalate stones. Not only was there a decrease in the absolute urine ammonium excretion of the uric acid stone formers but also the ammonium was low in relation to urine pH. Of 532 random urines tested in the uric acid group, before acid loading, 87.1 per cent had a pH 5.5 or less, compared to 37.1 per cent of 565 urines measured over the same pH range in the oxalate group. The defect responsible for the low urine pH and ammonia excretion in the uric acid group appeared to exert its effect primarily in the basal state since no difference was found, between the 2 stone-forming groups, in the increases of urine ammonia or in the decreases in urine pH during acid loading. It is suggested that the tendency of uric acid stone formers to excrete urines of consistently low pH contributes greatly to the pathogenesis of their stones. A rational explanation for the efficacy of alkalinization in the management of patients with uric acid calculi is provided by these findings. |
| Databáze: | OpenAIRE |
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