Prediction of recurrent venous thromboembolism by measuring ProC Global
| Autor: | Sabine Eichinger, Paul A. Kyrle, Christine Bialonczyk, Gregor Hron, Marietta Kollars, Erich Minar, Mirko Hirschl |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Risk Assessment Sensitivity and Specificity Gastroenterology Predictive Value of Tests Recurrence Internal medicine Odds Ratio medicine Humans In patient Prospective Studies cardiovascular diseases Vein Proportional Hazards Models business.industry Vascular disease Anticoagulants Venous Thromboembolism Hematology Middle Aged medicine.disease Surgery Venous thrombosis medicine.anatomical_structure Austria Relative risk Global function Female Partial Thromboplastin Time Reagent Kits Diagnostic business Venous thromboembolism Protein C Follow-Up Studies medicine.drug |
| Zdroj: | Thrombosis and Haemostasis. 98:1232-1236 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1160/th07-05-0376 |
| Popis: | SummaryIn patients with venous thromboembolism (VTE) a laboratory assay that globally measures the overall thrombophilic tendency is not available. We hypothesized that determination of ProC® Global, a plasma assay which tests the global function of the protein C pathway, could be used to stratify patients according to their risk of recurrent VTE. We prospectively followed 774 patients with first spontaneous VTE for a mean time of 52 months. ProC Global normalized ratio (NR) was measured in plasma by use of a commercially available assay based on activated partial thromboplastin time. Ninety-eight of the 774 patients had recurrent VTE. Patients with ProC Global NR ≥ 0.75 had a relative risk of recurrence of 0.59 (95% CI 0.40–0.87) as compared with those with lower ratio. After four years, cumulative probability of recurrence was 8.6% in patients with ProC Global NR ≥ 0.75 and 17.4% in patients with a lower ratio (p=0.006). Patients with a high ProC Global NR have a low risk of recurrent VTE. ProC Global NR can be used to stratify patients with a first unprovoked VTE according to their risk of recurrence. |
| Databáze: | OpenAIRE |
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