Decreased Anterior Cingulate Myo-inositol/Creatine Spectroscopy Resonance with Lithium Treatment in Children with Bipolar Disorder
| Autor: | Pablo Davanzo, Michael Strober, Thomas Oshiro, Thomas R. Belin, M. Albert Thomas, James T. McCracken, Kenneth Yue |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Bipolar Disorder Magnetic Resonance Spectroscopy Adolescent Lithium (medication) medicine.drug_class Lithium Creatine Gyrus Cinguli Sensitivity and Specificity Drug Administration Schedule chemistry.chemical_compound Internal medicine medicine Humans Bipolar disorder Child Anterior cingulate cortex Demography Pharmacology Aspartic Acid medicine.diagnostic_test Reproducibility of Results Magnetic resonance imaging Mood stabilizer medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Treatment Outcome medicine.anatomical_structure Endocrinology Hypomania chemistry Area Under Curve Cardiology Female Protons medicine.symptom Psychology Mania Inositol medicine.drug |
| Zdroj: | Neuropsychopharmacology. 24:359-369 |
| ISSN: | 0893-133X |
| Popis: | This project was designed to compare differences in brain proton spectra between children and adolescents with bipolar disorder (BPD) and gender and age-matched normal controls, and to measure changes in myo-inositol levels following lithium therapy, utilizing in vivo proton magnetic resonance spectroscopy (1H MRS). A single voxel (2x2x2 cm3) was placed in brain anterior cingulate cortex for acquisition of the 1H spectra at baseline and after acute (7 days) lithium administration in 11 children (mean age 11.4 years) diagnosed with BPD, and in 11 normal controls. Acute lithium treatment was associated with a significant reduction in the myo-inositol/creatine ratio. This decrement was also significant in lithium-responders when analyzed separate from non-responders. Compared to normal controls, BPD subjects showed a trend towards a higher myo-inositol/creatine during the manic phase. These preliminary data provide evidence that a significant reduction in anterior cingulate myo-inositol magnetic resonance may occur after lithium treatment, especially among responders. Follow-up studies involving a larger sample may allow us to confirm whether changes in myo-inositol associated with acute lithium therapy persist in long-term clinical response of patients with and without lithium compliance. |
| Databáze: | OpenAIRE |
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