Varicella-zoster Virus Symptoms and Polyneuropathy in a Patient with Human Immunodeficiency Virus Infection Not Improved until Highly Active Anti-retroviral Therapy Added to Acyclovir Therapy
| Autor: | Masayuki Murata, Yong Chong, Kouzaburo Yamaji, Shigeki Nabeshima, Yasuhiro Kishihara, Norihiro Furusyo, Hiroaki Takeoka, Jun Hayashi |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Acyclovir HIV Infections medicine.disease_cause Antiviral Agents Herpes Zoster Gastroenterology Lesion Polyneuropathies Immunity Antiretroviral Therapy Highly Active Internal medicine medicine Humans Blood test Palsy medicine.diagnostic_test business.industry Varicella zoster virus virus diseases General Medicine medicine.disease Dysphagia Virology Cytokine medicine.symptom business Polyneuropathy |
| Zdroj: | Journal of the Japanese Association for Infectious Diseases. 80:46-50 |
| ISSN: | 1884-569X 0387-5911 |
| Popis: | In March 2003, a 34-year-old man with left facial palsy, dysphagia, and hoarseness treated with acyclovir suffered worsened dermatological and neurological problems. A routine blood test in early April showed the patient to be HIV-antibody positive, so he was transferred to our hospital. Blood analysis showed serum HIV-RNA at 96,000 copies/mL and a CD 4 count of 170/microL. Brain MRI taken on admission showed a T 2 high lesion in their left medulla. Acyclovir was thought to be ineffective due to reduced cell-mediated immunity because of the HIV infection, and HAART therapy was begun. After two months of HAART, skin lesions and the T 2 high lesion in left medulla improred. HIV-RNA became undetectable and the CD 4 count exceeded 500/microL. Intracellular cytokine analysis by flow cytometry showed a shift from Th 2 to Th 1 dominance. The elimination of VZV may thus have been promoted by the combination of acyclovir and HAART. |
| Databáze: | OpenAIRE |
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