Antiplatelet Therapy in Coronary Artery Disease: A Daunting Dilemma
| Autor: | Aseem Vashist, Daniel Diver, Surya Chaturvedula |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Acute coronary syndrome
medicine.medical_specialty Prasugrel animal structures bare metal stent aspirin medicine.medical_treatment lcsh:Medicine Review 030204 cardiovascular system & hematology acute coronary syndrome ticagrelor Coronary artery disease 03 medical and health sciences 0302 clinical medicine medicine 030212 general & internal medicine oral anticoagulants Intensive care medicine Aspirin clopidogrel business.industry lcsh:R Percutaneous coronary intervention General Medicine medicine.disease Clopidogrel dual antiplatelet therapy prasugrel Drug-eluting stent triple therapy business Ticagrelor drug eluting stent coronary artery disease medicine.drug |
| Zdroj: | Journal of Clinical Medicine, Vol 7, Iss 4, p 74 (2018) Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| Popis: | Percutaneous coronary intervention (PCI) with stenting for the treatment of acute coronary syndrome (ACS) is the contemporary standard of care. Such treatment is followed by dual antiplatelet therapy (DAPT) comprising of aspirin and a P2Y12 inhibitor. The efficacy of this therapy has been well established but the optimal duration of DAPT remains elusive, and has thus far attracted a prodigious deal of scientific attention. The decision regarding DAPT duration can be clinically challenging in the modern era with the evolution of newer stents, more potent antiplatelet agents, and novel anticoagulant drugs in addition to an older patient population with multiple comorbidities. Major societal guidelines have emphasized comprehensive assessment of ischemic and bleeding risk, in turn recommending individualization of DAPT duration, thus encouraging “shared decision making”. The following review is aimed at critically evaluating the available evidence to help make these crucial clinical decisions regarding duration of DAPT and triple therapy. |
| Databáze: | OpenAIRE |
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