Successful Perioperative Management of Severe Bleeding From Undiagnosed Acquired Factor VIII Inhibitors
| Autor: | David W. Barbara, Aneel A. Ashrani, Sameer A. Parikh, William J. Mauermann, Rakesh M. Suri, Harold M. Burkhart, Rajiv K. Pruthi, Kyle M. McKenzie |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Critical Care Mucocutaneous zone Hemorrhage Hemophilia A Von Willebrand factor hemic and lymphatic diseases medicine Humans Mitral valve prolapse Cardiac Surgical Procedures Intraoperative Complications Blood coagulation test Factor IX Postoperative Care Mitral Valve Prolapse biology business.industry Middle Aged medicine.disease Surgery Cardiac surgery Anesthesiology and Pain Medicine Coagulation Hemostasis biology.protein Mitral Valve Blood Coagulation Tests Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Cardiothoracic and Vascular Anesthesia. 29:731-734 |
| ISSN: | 1053-0770 |
| DOI: | 10.1053/j.jvca.2013.10.015 |
| Popis: | ACQUIRED HEMOPHILIA A occurs as a result of development of inhibitory autoantibodies to factor VIII in the coagulation cascade. These antibodies result in impaired hemostasis and bleeding disorders of variable severities through varied mechanisms including impairment of binding of factor VIII to membrane phospholipids, factor IX, and/or von Willebrand factor. Common presentation includes mucocutaneous and soft tissue hemorrhage, although hemarthroses typically seen in severe congenital hemophilia A are rare. Most patients are diagnosed during the course of evaluation of bleeding symptoms, and for such patients requiring cardiac surgery, management has been described previously. The successful postoperative management of a case of acquired hemophilia A diagnosed perioperatively after cardiac surgery is reported here. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect