Analysis of 96 patients with advanced ovarian carcinoma treated with high-dose chemotherapy and autologous stem cell transplantation
| Autor: | Diane C. Bodurka, James Gajewski, Michael W. Bevers, Ana Aleman, Richard E. Champlin, David M. Gershenson, M. Donato, Robert C. Bast, Judith K. Wolf, Rima M. Saliba, Cindy Ippoliti, Thomas W. Burke, Ralph S. Freedman, J.T. Wharton, Charles F Levenback, Molly Brewer |
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| Rok vydání: | 2004 |
| Předmět: |
Oncology
Melphalan Adult medicine.medical_specialty Transplantation Conditioning medicine.medical_treatment ThioTEPA Transplantation Autologous Autologous stem-cell transplantation Internal medicine Antineoplastic Combined Chemotherapy Protocols Medicine Autologous transplantation Humans Aged Retrospective Studies Ovarian Neoplasms Transplantation Chemotherapy business.industry Hematopoietic Stem Cell Transplantation Hematology Middle Aged medicine.disease Survival Analysis Surgery Regimen Treatment Outcome Female business Progressive disease medicine.drug |
| Zdroj: | Bone marrow transplantation. 33(12) |
| ISSN: | 0268-3369 |
| Popis: | The purpose of this study was to identify characteristics significant to survival and progression-free survival in patients with advanced ovarian cancer receiving high-dose chemotherapy. In all, 96 patients received autologous stem cell transplantation. Regimens included paclitaxel with carboplatin (PC), topotecan, melphalan, cyclophosphamide (TMC) and cyclophosphamide, BCNU, thiotepa (CBT). At the time of transplantation, 43% of patients were in clinical CR, 34% were in clinical PR, 18% had progressive disease and 5% had stable disease. There were no treatment-related deaths. The 6-year survival by Kaplan-Meier was 38%. For patients who received transplantation for remission consolidation, the 6-year survival was 53% with a PFS of 29%. On univariate analysis, the CBT regimen, clear cell histology and disease status other than CR prior to treatment were statistically significant adverse prognostic factors. This analysis has demonstrated that patients in clinical remission are most likely to benefit from autologous transplantation, with the exception of patients with clear cell histology. The TMC combination appeared to be superior to the PC and CBT combinations. Comparative studies of different consolidation approaches will be necessary to determine if autologous transplantation is the preferred treatment for this patient population. |
| Databáze: | OpenAIRE |
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